Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells.
Raaijmakers M, Mukherjee S, Guo S, Kobayashi T, Schoonmaker J, Aung Z, Ebert B, Al-Shahrour F, Hasserjian R, Vallet S, Scadden E, Lin C, Scadden D. Niche Induced Myelodysplasia and Secondary Hematopoietic Neoplasia Caused by Deletion of Dicer1 in Osteoprogenitor Cells. Blood 2009, 114: 247. DOI: 10.1182/blood.v114.22.247.247.Peer-Reviewed Original ResearchDeletion of Dicer1Hematopoietic cellsMyelodysplastic syndromeHuman myelodysplastic syndromeOsteoprogenitor cellsHematopoietic abnormalitiesHematopoietic systemMesenchymal cellsWild-type environmentRegulation of hematopoiesisGene expression profilingWild-type hematopoietic cellsB cell progenitorsPrimitive hematopoietic cellsHematopoietic physiologyMiRNA biogenesisOrgan formationTranscriptional controlOsteolineage cellsNormal stem cellsGermline tissuesComparative genomic hybridizationMultiple lineagesExpression profilingBone marrow vascularity