Epor Stimulates Rapid Cycling and Larger Red Cells during Mouse and Human Erythropoiesis
Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Scalf S, Eastman A, Chen J, Zhu L, Heuberger J, Guo S, Koury M, Nordsborg N, Socolovsky M. Epor Stimulates Rapid Cycling and Larger Red Cells during Mouse and Human Erythropoiesis. Blood 2021, 138: 852. DOI: 10.1182/blood-2021-154403.Peer-Reviewed Original ResearchErythroid terminal differentiationCell divisionCell cycleWild-type erythroblastsAnti-apoptotic protein BclCell sizeLive-cell reporterCell cycle speedNon-redundant functionsLarger red cellsFetal liver progenitorsTransferrin receptorEIF2α kinaseEpoR functionErythroblast survivalGenetic systemProtein BclHuman erythropoiesisNegative regulatorSurvival signalsTerminal differentiationEffects of EpoEpoRMouse EpoRP27 Kip1