2021
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis
Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Maxwell Scalf S, Eastman AE, Chen JJ, Zhu LJ, Heuberger JAAC, Guo S, Koury MJ, Nordsborg NB, Socolovsky M. EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nature Communications 2021, 12: 7334. PMID: 34921133, PMCID: PMC8683474, DOI: 10.1038/s41467-021-27562-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntigens, CDBcl-X ProteinCD4 AntigensCell CycleCell DifferentiationCell NucleusCell SizeCell SurvivalCyclin-Dependent Kinase Inhibitor p27Embryo, MammalianErythroblastsErythrocytesErythropoiesisErythropoietinFemaleFetusHealthy VolunteersHumansIronLiverMaleMice, Inbred C57BLModels, BiologicalProtein Serine-Threonine KinasesReceptors, ErythropoietinReceptors, TransferrinReticulocytesSignal TransductionConceptsCell size regulationCell sizeSequential cell divisionsEpoR functionErythroblast survivalMouse erythroblastsCell divisionSize regulationHuman erythropoiesisErythropoietin receptorCell cycleEpoRHypoxic stressRed cell sizeHigh erythropoietinLarger red cellsWild-type miceCyclingErythroblastsRegulationHigher EPO levelsMiceRed cellsSurvivalErythropoiesisEpor Stimulates Rapid Cycling and Larger Red Cells during Mouse and Human Erythropoiesis
Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Scalf S, Eastman A, Chen J, Zhu L, Heuberger J, Guo S, Koury M, Nordsborg N, Socolovsky M. Epor Stimulates Rapid Cycling and Larger Red Cells during Mouse and Human Erythropoiesis. Blood 2021, 138: 852. DOI: 10.1182/blood-2021-154403.Peer-Reviewed Original ResearchErythroid terminal differentiationCell divisionCell cycleWild-type erythroblastsAnti-apoptotic protein BclCell sizeLive-cell reporterCell cycle speedNon-redundant functionsLarger red cellsFetal liver progenitorsTransferrin receptorEIF2α kinaseEpoR functionErythroblast survivalGenetic systemProtein BclHuman erythropoiesisNegative regulatorSurvival signalsTerminal differentiationEffects of EpoEpoRMouse EpoRP27 Kip1
2020
Reprogramming progressive cells display low CAG promoter activity
Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, Eastman AE, Park I, Guo S. Reprogramming progressive cells display low CAG promoter activity. Stem Cells 2020, 39: 43-54. PMID: 33075202, PMCID: PMC7821215, DOI: 10.1002/stem.3295.Peer-Reviewed Original Research