A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis
Leopold S, Magrini V, Holt N, Shaikh N, Mardis E, Cagno J, Ogura Y, Iguchi A, Hayashi T, Mellmann A, Karch H, Besser T, Sawyer S, Whittam T, Tarr P. A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 8713-8718. PMID: 19439656, PMCID: PMC2689004, DOI: 10.1073/pnas.0812949106.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsEffective population sizeSynonymous single nucleotide polymorphismsClusters of organismsGene clusterSpecies evolutionGenome regionsEvolutionary dynamicsPathogenic Escherichia coli O157Selective advantageEscherichia coli O157Related pathogensPopulation sizeNucleotide polymorphismsTenuous survivalPathogenic O157Coli O157OrganismsFalse associationsPathogensORFH7Backbone regionO157Mutations