Bacterial Whole-Genome Sequencing Revisited: Portable, Scalable, and Standardized Analysis for Typing and Detection of Virulence and Antibiotic Resistance Genes
Leopold S, Goering R, Witten A, Harmsen D, Mellmann A. Bacterial Whole-Genome Sequencing Revisited: Portable, Scalable, and Standardized Analysis for Typing and Detection of Virulence and Antibiotic Resistance Genes. Journal Of Clinical Microbiology 2014, 52: 2365-2370. PMID: 24759713, PMCID: PMC4097726, DOI: 10.1128/jcm.00262-14.Peer-Reviewed Original ResearchConceptsIntensive care unitMethicillin-resistant Staphylococcus aureusEffective infection controlInfection controlEpidemiological investigationsWhole-genome sequencingAntibiotic resistanceMultidrug-resistant nosocomial pathogenAntibiotic resistance profilesToxin gene profilesMRSA casesMRSA clustersCare unitRegular screeningNosocomial infectionsDetection of virulenceMajor burdenNosocomial pathogenS. aureus proteinSusceptibility profilesResistance profilesClonal clustersWGS resultsTransmission eventsBacterial whole-genome sequencing