Effects of Proteasome Inhibition in the Anti-Tumor Activity of Venetoclax in Mantle Cell Lymphoma Pre-Clinical Models
Kothari S, Mavis C, Gu J, Hernandez-Ilizaliturri F. Effects of Proteasome Inhibition in the Anti-Tumor Activity of Venetoclax in Mantle Cell Lymphoma Pre-Clinical Models. Blood 2018, 132: 2942. DOI: 10.1182/blood-2018-99-116510.Peer-Reviewed Original ResearchMantle cell lymphomaAnti-tumor activityPre-clinical modelsRefractory mantle cell lymphomaB-cell lymphoma patientsPrimary tumor cellsMCL cell linesCell cycle regulatory proteinsResistant cell linesProteasome inhibitorsHBL-2 cellsLymphoma patientsCycle regulatory proteinsSCID miceSCID animalsCell linesAutologous stem cell rescueTumor cellsHigh-dose chemotherapyStem cell rescueSignificant anti-tumor activitySynergistic activityNovel therapeutic strategiesNovel proteasome inhibitorSelective BCL-2 inhibitor