Pevonedistat, a NEDD8‐activating enzyme inhibitor, induces apoptosis and augments efficacy of chemotherapy and small molecule inhibitors in pre‐clinical models of diffuse large B‐cell lymphoma
Torka P, Mavis C, Kothari S, Belliotti S, Gu J, Sundaram S, Barth M, Hernandez‐Ilizaliturri F. Pevonedistat, a NEDD8‐activating enzyme inhibitor, induces apoptosis and augments efficacy of chemotherapy and small molecule inhibitors in pre‐clinical models of diffuse large B‐cell lymphoma. EJHaem 2020, 1: 122-132. PMID: 33073261, PMCID: PMC7566777, DOI: 10.1002/jha2.2.Peer-Reviewed Original ResearchActivated B cellsPre-clinical modelsSmall molecule inhibitorsClass NEDD8-activating enzyme (NAE) inhibitorEnzyme inhibitorsSCID mouse xenograft modelDiffuse large B-cell lymphomaCell linesLarge B-cell lymphomaActivity of cytarabineCytotoxic chemotherapy agentsFurther clinical studiesB-cell lymphomaViable therapeutic strategyMouse xenograft modelMolecule inhibitorsB-cell lymphoma cell linesDLBCL cell linesGCB-DLBCL cell linesLarge B-cell lymphoma cell linesAugments efficacyChemotherapy agentsClinical studiesLymphoma cell linesMonotherapy controls