Deep Sequencing of HIV: Clinical and Research Applications
Chabria SB, Gupta S, Kozal MJ. Deep Sequencing of HIV: Clinical and Research Applications. Annual Review Of Genomics And Human Genetics 2014, 15: 1-31. PMID: 24821496, DOI: 10.1146/annurev-genom-091212-153406.BooksMeSH KeywordsDrug Resistance, ViralGenome, ViralHigh-Throughput Nucleotide SequencingHIVHIV InfectionsHumansMutationConceptsHuman immunodeficiency virusAntiretroviral therapyDrug-resistant human immunodeficiency virusDrug-resistant HIV variantsCare antiretroviral therapyMaximal viral suppressionTreatment-naive individualsDrug resistance mutationsViral quasispeciesViral suppressionDrug selective pressureAntiretroviral agentsSensitive genotyping methodsTreatment failureHIV transmissionImmunodeficiency virusHIV variantsClinical careVaccine developmentViral variantsViral heterogeneityMolecular virologyLow-frequency variantsViral fitnessSequencing-based assays