An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids
Alexander B, Bartfield N, Gupta V, Mercado B, Del Campo M, Herzon S. An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids. Science 2024, 383: 849-854. PMID: 38386756, DOI: 10.1126/science.adl6163.Peer-Reviewed Original ResearchConceptsFunctional group manipulationsMicrocrystal electron diffractionOxidative photocyclizationAdvanced intermediateGroup manipulationsHeterocyclic residuesOxide ringSynthetic accessibilityElectron diffractionTarget identification studiesReactive alkenesModular assemblyCytotoxic alkaloidFlexible routeAlkenesIdentification studiesAlkaloidsPhotocycleDiffractionStructural complexityStructureRingIntermediateChemistrySynthesis