Dynamics of Base Excision Repair at the Maternal–Fetal Interface in Pregnancies Complicated by Preeclampsia
Tadesse S, Norwitz NG, Guller S, Arcuri F, Toti P, Norwitz ER, Kidane D. Dynamics of Base Excision Repair at the Maternal–Fetal Interface in Pregnancies Complicated by Preeclampsia. Reproductive Sciences 2017, 24: 856-864. PMID: 27707956, DOI: 10.1177/1933719116670519.Peer-Reviewed Original ResearchConceptsMaternal-fetal interfaceOxidative stressNormotensive controlsPlacental tissueHypoxia/reperfusion (H/R) modelPlacental endothelial dysfunctionPlacentas of womenHealthy control subjectsApyrimidinic endonuclease 1PE placental tissuesPregnancy ComplicatedEndothelial dysfunctionPreeclamptic womenPerinatal mortalityReperfusion modelControl subjectsDecidual cellsPathological basisVivo comparative studyPreeclampsiaMaternal cellsFetal cellsAPE1 expressionSignificant increaseWomen