H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction
Zuckerwise L, Li J, Lu L, Men Y, Geng T, Buhimschi CS, Buhimschi IA, Bukowski R, Guller S, Paidas M, Huang Y. H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction. Oncotarget 2016, 7: 38398-38407. PMID: 27223264, PMCID: PMC5122399, DOI: 10.18632/oncotarget.9534.Peer-Reviewed Original ResearchMeSH KeywordsCell MovementDown-RegulationFemaleFetal Growth RetardationHumansPlacentaPregnancyReceptors, Transforming Growth Factor betaRNA, Long NoncodingTransfectionTrophoblastsConceptsFetal growth restrictionGrowth restrictionExtravillous trophoblastsDownregulation of H19Type III TGF-β receptorCell migrationEVT cell migrationNon-canonical TGFTGF-β receptorFGR placentasNeurodevelopmental impairmentPerinatal mortalityRisk factorsTherapeutic modalitiesEVT cellsH19 knockdownOnset disordersPlacentaInvasionMolecular mechanismsH19Let-7Novel regulatory targetMorbidityRegulatory pathways