2014
Trophoblast Induces Monocyte Differentiation Into CD14+/CD16+ Macrophages
Aldo PB, Racicot K, Craviero V, Guller S, Romero R, Mor G. Trophoblast Induces Monocyte Differentiation Into CD14+/CD16+ Macrophages. American Journal Of Reproductive Immunology 2014, 72: 270-284. PMID: 24995492, PMCID: PMC4230492, DOI: 10.1111/aji.12288.Peer-Reviewed Original ResearchConceptsUnique macrophage phenotypeMacrophage phenotypeMonocyte differentiationFirst trimester trophoblast cellsPeripheral blood monocytesPhenotype of macrophagesCD14 surface expressionNormal deciduaHealthy pregnancyIL-10Chemokine productionEarly pregnancyIP-10Monocyte exposureIL-1BBlood monocytesDecidual phenotypePhagocytic capacityTrophoblast cellsFlow cytometryMorphologic changesMacrophagesMonocytesSurface expressionPlacenta development
2003
Glucocorticoid Enhances Transforming Growth Factor-β Effects on Extracellular Matrix Protein Expression in Human Placental Mesenchymal Cells1
Lee MJ, Ma Y, LaChapelle L, Kadner SS, Guller S. Glucocorticoid Enhances Transforming Growth Factor-β Effects on Extracellular Matrix Protein Expression in Human Placental Mesenchymal Cells1. Biology Of Reproduction 2003, 70: 1246-1252. PMID: 14681196, DOI: 10.1095/biolreprod.103.021956.Peer-Reviewed Original ResearchConceptsPlacental mesenchymal cellsIntrauterine growth restrictionFFN levelsProtein expressionCol IV expressionInteraction of glucocorticoidsDose-dependent mannerHuman term placentaFibronectin protein levelsExtracellular matrix protein expressionUncomplicated pregnanciesPolymerase chain reaction analysisReal-time polymerase chain reaction analysisGrowth restrictionDEX treatmentChain reaction analysisECM proteinsPlacental villiTerm placentaECM protein expressionCol IIIPlacental architectureMatrix protein expressionDexamethasoneGlucocorticoids
2002
Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β
Ma Y, Ryu JS, Dulay A, Segal M, Guller S. Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β. Placenta 2002, 23: 727-734. PMID: 12398812, DOI: 10.1053/plac.2002.0863.Peer-Reviewed Original ResearchConceptsHTR-8/SVneo cellsIntrauterine growth restrictionPAI-2 levelsPAI-1 expressionPlasminogen activator inhibitorActivator inhibitorGrowth factorHuman trophoblast cell linePAI-1 levelsTrophoblast cell lineTransforming Growth FactorTGF-beta treatmentTGF-beta effectsPAI-1 proteinFibrin depositionGrowth restrictionDEX treatmentSynthetic glucocorticoidGlucocorticoidsPAI-1Regulation of fibrinolysisDexamethasoneTGF betaExcessive productionMRNA expression