2018
Glucocorticoid signaling regulates cell invasion and migration in the human first‐trimester trophoblast cell line Sw.71
Kisanga EP, Tang Z, Guller S, Whirledge S. Glucocorticoid signaling regulates cell invasion and migration in the human first‐trimester trophoblast cell line Sw.71. American Journal Of Reproductive Immunology 2018, 80: e12974. PMID: 29774963, DOI: 10.1111/aji.12974.Peer-Reviewed Original ResearchConceptsGene expression profilesSERPINE1 promoterPolymerase IITranscriptional regulationGlucocorticoid receptorCell movementTranscriptional profilesGlucocorticoid treatmentExpression profilesMicroarray analysisStress responseCell invasionPrimary mediatorPathogenesis of preeclampsiaCell proliferationEffects of glucocorticoidsExtravillous trophoblast functionsGlucocorticoid signalingSynthetic glucocorticoid dexamethasoneGenesTrophoblast functionsAdrenal axisInvasionTrophoblast tissueGlucocorticoid dexamethasone
2002
Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β
Ma Y, Ryu JS, Dulay A, Segal M, Guller S. Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β. Placenta 2002, 23: 727-734. PMID: 12398812, DOI: 10.1053/plac.2002.0863.Peer-Reviewed Original ResearchConceptsHTR-8/SVneo cellsIntrauterine growth restrictionPAI-2 levelsPAI-1 expressionPlasminogen activator inhibitorActivator inhibitorGrowth factorHuman trophoblast cell linePAI-1 levelsTrophoblast cell lineTransforming Growth FactorTGF-beta treatmentTGF-beta effectsPAI-1 proteinFibrin depositionGrowth restrictionDEX treatmentSynthetic glucocorticoidGlucocorticoidsPAI-1Regulation of fibrinolysisDexamethasoneTGF betaExcessive productionMRNA expression