2012
Cutting‐Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan‐Induced Trophoblast Apoptosis
Mulla MJ, Myrtolli K, Tadesse S, Stanwood NL, Gariepy A, Guller S, Norwitz ER, Abrahams VM. Cutting‐Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan‐Induced Trophoblast Apoptosis. American Journal Of Reproductive Immunology 2012, 69: 449-453. PMID: 23279063, PMCID: PMC3620725, DOI: 10.1111/aji.12065.Peer-Reviewed Original ResearchConceptsIL-6 secretionTrophoblast apoptosisTLR2 coreceptorsHuman trophoblast cell lineIntrauterine bacterial infectionFirst-trimester human trophoblast cell lineThird-trimester human placental tissueHuman placental tissueTrophoblast cell linePositive bacterial componentsTLR10 expressionPreterm laborThird trimesterCaspase-3 activityIL-6TLR2 activationPlacental tissuePlacental apoptosisBacterial infectionsTLR10Bacterial componentsBacterial peptidoglycanTrophoblastCell linesApoptosis
2007
Expression of Toll-like receptors in the human decidua.
Krikun G, Lockwood CJ, Abrahams VM, Mor G, Paidas M, Guller S. Expression of Toll-like receptors in the human decidua. Histology And Histopathology 2007, 22: 847-54. PMID: 17503341, DOI: 10.14670/hh-22.847.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportCells, CulturedDeciduaEndometriumEndothelial CellsFemaleHumansImmunity, InnateImmunohistochemistryInterleukinsLipopolysaccharidesMyeloid Differentiation Factor 88NF-kappa BPeptidoglycanPoly I-CPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionToll-Like ReceptorsConceptsToll-like receptorsHuman deciduaFirst trimester elective terminationMaternal spiral arteriesInnate immune responseCesarean sectionSpiral arteriesThird trimesterCytokine productionElective terminationDecidual tissuesImmune responseLate gestationPregnant endometriumFetal membranesSurveillance moleculeHost defensePregnancyDeciduaMRNA levelsReceptorsMicrobial pathogensTrimesterEndometriumArteryCell Type-specific Expression and Function of Toll-like Receptors 2 and 4 in Human Placenta: Implications in Fetal Infection
Ma Y, Krikun G, Abrahams VM, Mor G, Guller S. Cell Type-specific Expression and Function of Toll-like Receptors 2 and 4 in Human Placenta: Implications in Fetal Infection. Placenta 2007, 28: 1024-1031. PMID: 17588655, PMCID: PMC2064901, DOI: 10.1016/j.placenta.2007.05.003.Peer-Reviewed Original ResearchConceptsInnate immune responseIL-8 levelsToll-like receptorsTLR-4Immune responseTLR-2TLR functionTerm placentaToll-like receptor 2Endothelial cellsAdverse fetal outcomesTLR-2 expressionMaternal-fetal interfacePathogen-associated molecular patternsHuman term placentaCell type-specific expressionGram-negative bacterial lipopolysaccharideFetal outcomesPlacental infectionTLR expressionFetal infectionLPS treatmentMajor cell typesImmunohistochemical analysisStem villi