2020
Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua
Silasi M, You Y, Simpson S, Kaislasuo J, Pal L, Guller S, Peng G, Ramhorst R, Grasso E, Etemad S, Durosier S, Aldo P, Mor G. Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human decidua. Scientific Reports 2020, 10: 5785. PMID: 32238853, PMCID: PMC7113245, DOI: 10.1038/s41598-020-62593-9.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinCXCL10 expressionChorionic gonadotropinPotent immune-modulatory effectsImmune system undergoesImmune modulatory effectsEndometrial stromal cellsImmune cell recruitmentMaternal-fetal interfaceImmune regulatory functionsProcess of implantationCD8 cellsCytokine profilePregnancy progressesFetal interfaceDecidual samplesImmune populationsImmune factorsHuman deciduaT cellsDecidual cellsCell recruitmentModulatory effectsEarly hormoneStromal cells
2014
In Vivo and In Vitro Evidence for Placental DNA Damage in Preeclampsia
Tadesse S, Kidane D, Guller S, Luo T, Norwitz NG, Arcuri F, Toti P, Norwitz ER. In Vivo and In Vitro Evidence for Placental DNA Damage in Preeclampsia. PLOS ONE 2014, 9: e86791. PMID: 24466242, PMCID: PMC3899334, DOI: 10.1371/journal.pone.0086791.Peer-Reviewed Original ResearchConceptsDecidual stromal cellsCytotrophoblast cellsMaternal decidual stromal cellsReactive oxygen speciesPlacental oxidative stressFetal-maternal interfaceDNA damagePE placental tissuesAnti-oxidant defensesMultisystem diseasePregnant womenPE placentasFetal sideMaternal deciduaOxidative DNA damagePreeclampsiaPlacental tissueNormal placentaStromal cellsPlacentaOxidative stressVitro EvidenceRepair responseDNA damage/repair responseΓH2AX foci
2012
Toll‐Like Receptor 4 Expression in Decidual Cells and Interstitial Trophoblasts Across Human Pregnancy
Schatz F, Kayisli UA, Vatandaslar E, Ocak N, Guller S, Abrahams VM, Krikun G, Lockwood CJ. Toll‐Like Receptor 4 Expression in Decidual Cells and Interstitial Trophoblasts Across Human Pregnancy. American Journal Of Reproductive Immunology 2012, 68: 146-153. PMID: 22564191, PMCID: PMC3395732, DOI: 10.1111/j.1600-0897.2012.01148.x.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Interstitial trophoblastDecidual cellsDanger signalsToll-like receptor 4 expressionFirst trimester decidual cellsReceptor 4 expressionHuman pregnancyElective terminationNormal deliveryDecidua parietalisReceptor 4Luteal phaseStromal cellsGram-negative bacteriaSerial sectionsTrophoblastPrimary targetCellsClose contactEndometriumPregnancyHScoreGestationCytokeratin
2010
Role of GnRH–GnRH receptor signaling at the maternal-fetal interface
Lee HJ, Snegovskikh VV, Park JS, Foyouzi N, Han KT, Hodgson EJ, Guller S, Norwitz ER. Role of GnRH–GnRH receptor signaling at the maternal-fetal interface. Fertility And Sterility 2010, 94: 2680-2687. PMID: 20400076, DOI: 10.1016/j.fertnstert.2010.03.016.Peer-Reviewed Original ResearchConceptsGnRHR-I mRNAMaternal-fetal interfaceDecidual stromal cellsHCG productionGnRH-IISelect cytokinesTrophoblast cellsCell linesEffects of GnRHUniversity Teaching HospitalExpression of GnRHFunction of GnRHReverse transcription-polymerase chain reactionDose-dependent fashionHuman trophoblast cellsTerm deliveryPolymerase chain reactionTeaching hospitalGnRH receptorMAIN OUTCOMEGnRHHuman trophoblastsStromal cellsWestern blotImmortalized cell lines
2004
A Novel Immortalized Human Endometrial Stromal Cell Line with Normal Progestational Response
Krikun G, Mor G, Alvero A, Guller S, Schatz F, Sapi E, Rahman M, Caze R, Qumsiyeh M, Lockwood CJ. A Novel Immortalized Human Endometrial Stromal Cell Line with Normal Progestational Response. Endocrinology 2004, 145: 2291-2296. PMID: 14726435, DOI: 10.1210/en.2003-1606.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TransformedDeciduaEndometriumEstradiolFas Ligand ProteinFas ReceptorFemaleFibronectinsGene ExpressionHot TemperatureHumansInsulin-Like Growth Factor Binding Protein 1KaryotypingMedroxyprogesterone AcetateMembrane GlycoproteinsPlasminogen Activator Inhibitor 1ProgestinsProlactinStromal CellsTelomeraseThromboplastinConceptsHuman endometrial stromal cellsImmortalized human endometrial stromal cell lineHuman endometrial stromal cell lineCultured human endometrial stromal cellsEndometrial stromal cell linePrimary human endometrial stromal cellsPlasminogen activator inhibitor-1Endometrial stromal cellsExpression of IGFFas/Fas ligandActivator inhibitor-1Cell linesProgestational responseParent cellsOvarian steroidsMedroxyprogesterone acetateDecidualization responseAbnormal karyotypeStromal cell lineTissue factorNew cell lineStromal cellsFas ligandInhibitor-1Process of immortalization