2014
Human Fetal Membranes Generate Distinct Cytokine Profiles in Response to Bacterial Toll-Like Receptor and Nod-Like Receptor Agonists1
Hoang M, Potter JA, Gysler SM, Han CS, Guller S, Norwitz ER, Abrahams VM. Human Fetal Membranes Generate Distinct Cytokine Profiles in Response to Bacterial Toll-Like Receptor and Nod-Like Receptor Agonists1. Biology Of Reproduction 2014, 90: 39, 1-9. PMID: 24429216, PMCID: PMC4076407, DOI: 10.1095/biolreprod.113.115428.Peer-Reviewed Original ResearchConceptsBacterial toll-like receptorsToll-like receptorsPathogen-associated molecular patternsInnate immune pattern recognition receptorsNOD-like receptorsPattern recognition receptorsImmune pattern recognition receptorsCytokine profileIL1B secretionFetal membranesCpG ODNCaspase-1Subsequent preterm birthInflammatory cytokine profilePreterm premature ruptureDistinct cytokine profilesMaternal-fetal interfaceInfection-associated inflammationMild stimulatory effectNLR agonistsPreterm birthPremature ruptureProinflammatory cytokinesCytokine productionMCP-1
2005
Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes*
Stephenson CD, Lockwood CJ, Ma Y, Guller S. Thrombin-dependent regulation of matrix metalloproteinase (MMP)-9 levels in human fetal membranes*. The Journal Of Maternal-Fetal & Neonatal Medicine 2005, 18: 17-22. PMID: 16105787, DOI: 10.1080/14767050500123632.Peer-Reviewed Original ResearchConceptsMMP-9 levelsMMP-9MMP-1Matrix metalloproteinaseAmniochorionic membranesThrombin receptor agonist peptidePreterm premature ruptureAnti-inflammatory steroidsMajor risk factorMMP-9 expressionThrombin treatmentThrombin receptor agonistPresence of lipopolysaccharideHuman fetal membranesPremature ruptureReceptor agonistRisk factorsSuch hemorrhageDEX treatmentMMP levelsTIMP-1Thrombin receptorTissue inhibitorAgonist peptideFetal membranes