2006
Differential Release of Plasminogen Activator Inhibitors (PAIs) During Dual Perfusion of Human Placenta: Implications in Preeclampsia
Guller S, Ma Y, Malek A, Di Santo S, Schneider H. Differential Release of Plasminogen Activator Inhibitors (PAIs) During Dual Perfusion of Human Placenta: Implications in Preeclampsia. Placenta 2006, 28: 278-285. PMID: 16820203, DOI: 10.1016/j.placenta.2006.05.005.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionPAI-1 levelsPlasminogen activator inhibitorTotal PAI-1 levelsMaternal perfusateDual perfusionTime-dependent increaseReactive oxygen speciesRelease of PAIActivator inhibitorIntervillous fibrin depositionActive PAI-1 levelsSignificant time-dependent increasePAI-2 levelsPAI-1 releaseHuman term placentaPlacental tissue extractsAberrant fibrinolysisPlacental infarctionMaternal serumFibrin depositionGrowth restrictionIntervillous spacePreeclampsiaTerm placenta
2002
Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β
Ma Y, Ryu JS, Dulay A, Segal M, Guller S. Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β. Placenta 2002, 23: 727-734. PMID: 12398812, DOI: 10.1053/plac.2002.0863.Peer-Reviewed Original ResearchConceptsHTR-8/SVneo cellsIntrauterine growth restrictionPAI-2 levelsPAI-1 expressionPlasminogen activator inhibitorActivator inhibitorGrowth factorHuman trophoblast cell linePAI-1 levelsTrophoblast cell lineTransforming Growth FactorTGF-beta treatmentTGF-beta effectsPAI-1 proteinFibrin depositionGrowth restrictionDEX treatmentSynthetic glucocorticoidGlucocorticoidsPAI-1Regulation of fibrinolysisDexamethasoneTGF betaExcessive productionMRNA expression