2010
Protein composition of microparticles shed from human placenta during placental perfusion: Potential role in angiogenesis and fibrinolysis in preeclampsia
Guller S, Tang Z, Ma YY, Di Santo S, Sager R, Schneider H. Protein composition of microparticles shed from human placenta during placental perfusion: Potential role in angiogenesis and fibrinolysis in preeclampsia. Placenta 2010, 32: 63-69. PMID: 21074265, PMCID: PMC3762591, DOI: 10.1016/j.placenta.2010.10.011.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitorMaternal perfusateSFlt-1Maternal endothelial cell dysfunctionFms-like tyrosine kinasePathophysiology of preeclampsiaMaternal-fetal interfaceEndothelial cell dysfunctionAnti-angiogenic actionFollowing relative levelsPlacental damagePlacental perfusionMaternal serumNormal pregnancyPlacental pathophysiologyAnnexin V bindingSyncytiotrophoblast microparticlesDual perfusionAngiogenic balanceCell dysfunctionMaternal bloodPreeclampsiaActivator inhibitorCytometric analysisLevel of expression
2009
Role of the syncytium in placenta-mediated complications of preeclampsia
Guller S. Role of the syncytium in placenta-mediated complications of preeclampsia. Thrombosis Research 2009, 124: 389-392. PMID: 19535132, PMCID: PMC2764997, DOI: 10.1016/j.thromres.2009.05.016.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Fms-like tyrosine kinase-1Complications of preeclampsiaIntrauterine growth restrictionPathophysiology of preeclampsiaTyrosine kinase-1Immune cell functionAnti-angiogenic factorsActivator inhibitor-1Potential protective actionMaternal hemostasisSoluble endoglinEndothelial functionReperfusion injuryMaternal endotheliumMaternal mortalityRelease of microparticlesGrowth restrictionMaternal bloodPreeclampsiaSensitive markerMajor causeInhibitor-1Protective actionReactive oxygen species
2008
The Placental Syncytium and the Pathophysiology of Preeclampsia and Intrauterine Growth Restriction
Guller S, Y. Y, Fu H, Krikun G, Abrahams VM, Mor G. The Placental Syncytium and the Pathophysiology of Preeclampsia and Intrauterine Growth Restriction. Annals Of The New York Academy Of Sciences 2008, 1127: 129-133. PMID: 18443340, PMCID: PMC3671376, DOI: 10.1196/annals.1434.015.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionPathophysiology of preeclampsiaGrowth restrictionPlacental syncytiumFms-like tyrosine kinase-1Complications of pregnancyPlasminogen activator inhibitor-1Tyrosine kinase-1Activator inhibitor-1Release of factorsPlacental damageSoluble endoglinEndothelium dysfunctionLaser capture microdissectionMaternal bloodAntiangiogenic factorsPreeclampsiaFas ligandWestern blottingInhibitor-1Reactive oxygen speciesCapture microdissectionPregnancyPathophysiologyKinase 1
2007
Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction
Bahtiyar MO, Buhimschi C, Ravishankar V, Copel J, Norwitz E, Julien S, Guller S, Buhimschi IA. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. American Journal Of Obstetrics And Gynecology 2007, 196: 72.e1-72.e6. PMID: 17240241, DOI: 10.1016/j.ajog.2006.07.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChronic DiseaseDisease Models, AnimalEnzyme InhibitorsFemaleFetal Growth RetardationHypoxiaNG-Nitroarginine Methyl EsterNitric Oxide SynthasePlacenta Growth FactorPregnancyPregnancy ProteinsRatsRats, Sprague-DawleyVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsVascular endothelial growth factorL-NAMESerum levelsChronic hypoxiaSoluble fms-like tyrosine kinase-1Nitro-L-arginine methyl esterFms-like tyrosine kinase-1Adult Sprague-Dawley ratsGrowth factorMaternal serum levelsFree serum levelsIntrauterine growth restrictionOnset of laborPlacental growth factorTyrosine kinase-1Subcutaneous osmotic pumpsSprague-Dawley ratsNitric oxide inhibitionEndothelial growth factorNonpregnant controlsSFlt-1Growth restrictionHypoxic chamberMaternal bloodOxide inhibition
2005
Alterations in Syncytiotrophoblast Cytokine Expression Following Treatment with Lipopolysaccharide
Ma Y, Mor G, Abrahams VM, Buhimschi IA, Buhimschi CS, Guller S. Alterations in Syncytiotrophoblast Cytokine Expression Following Treatment with Lipopolysaccharide. American Journal Of Reproductive Immunology 2005, 55: 12-18. PMID: 16364007, DOI: 10.1111/j.1600-0897.2005.00347.x.Peer-Reviewed Original ResearchConceptsCytokine expressionLPS treatmentInflammatory compoundsAnti-inflammatory cytokinesIL-8 levelsInterleukin-8 levelsAnti-inflammatory compoundsEnzyme-linked immunosorbent assayCell typesCytokine levelsGlucocorticoid treatmentMaternal bloodDEX treatmentPlacental syncytiumSyncytiotrophoblastImmunosorbent assayLPSPrimary culturesTreatmentCytokinesFourfold increaseExpressionSyncytiaGestationLevels