2017
Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.
Cross SN, Potter JA, Aldo P, Kwon JY, Pitruzzello M, Tong M, Guller S, Rothlin CV, Mor G, Abrahams VM. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. The Journal Of Immunology 2017, 199: 2885-2895. PMID: 28916522, PMCID: PMC5659726, DOI: 10.4049/jimmunol.1700870.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedChorioamnionitisC-Mer Tyrosine KinaseExtraembryonic MembranesFemaleGammaherpesvirinaeHerpesviridae InfectionsHerpesvirus 2, HumanHumansImmunizationInflammasomesIntercellular Signaling Peptides and ProteinsInterleukin-1betaLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutPregnancyPremature BirthProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesConceptsFetal membranesViral infectionImmune responseTAM receptorsSubsequent preterm birthAdverse pregnancy outcomesIL-1β productionIL-1β responseHerpes viral infectionsInnate immune responseVivo mouse modelHuman fetal membranesAggravated inflammationIL-1β processingPregnancy outcomesPreterm birthAssociated complicationsPremature rupturePregnant womenLocal infectionInflammasome activationMerTK inhibitionMouse modelBacterial LPSLigand expression
2007
Expression of Toll-like receptors in the human decidua.
Krikun G, Lockwood CJ, Abrahams VM, Mor G, Paidas M, Guller S. Expression of Toll-like receptors in the human decidua. Histology And Histopathology 2007, 22: 847-54. PMID: 17503341, DOI: 10.14670/hh-22.847.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportCells, CulturedDeciduaEndometriumEndothelial CellsFemaleHumansImmunity, InnateImmunohistochemistryInterleukinsLipopolysaccharidesMyeloid Differentiation Factor 88NF-kappa BPeptidoglycanPoly I-CPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionToll-Like ReceptorsConceptsToll-like receptorsHuman deciduaFirst trimester elective terminationMaternal spiral arteriesInnate immune responseCesarean sectionSpiral arteriesThird trimesterCytokine productionElective terminationDecidual tissuesImmune responseLate gestationPregnant endometriumFetal membranesSurveillance moleculeHost defensePregnancyDeciduaMRNA levelsReceptorsMicrobial pathogensTrimesterEndometriumArteryCell Type-specific Expression and Function of Toll-like Receptors 2 and 4 in Human Placenta: Implications in Fetal Infection
Ma Y, Krikun G, Abrahams VM, Mor G, Guller S. Cell Type-specific Expression and Function of Toll-like Receptors 2 and 4 in Human Placenta: Implications in Fetal Infection. Placenta 2007, 28: 1024-1031. PMID: 17588655, PMCID: PMC2064901, DOI: 10.1016/j.placenta.2007.05.003.Peer-Reviewed Original ResearchConceptsInnate immune responseIL-8 levelsToll-like receptorsTLR-4Immune responseTLR-2TLR functionTerm placentaToll-like receptor 2Endothelial cellsAdverse fetal outcomesTLR-2 expressionMaternal-fetal interfacePathogen-associated molecular patternsHuman term placentaCell type-specific expressionGram-negative bacterial lipopolysaccharideFetal outcomesPlacental infectionTLR expressionFetal infectionLPS treatmentMajor cell typesImmunohistochemical analysisStem villi
2005
A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells
Abrahams VM, Visintin I, Aldo PB, Guller S, Romero R, Mor G. A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells. The Journal Of Immunology 2005, 175: 8096-8104. PMID: 16339547, DOI: 10.4049/jimmunol.175.12.8096.Peer-Reviewed Original ResearchConceptsFirst trimester trophoblast cellsInnate immune cellsMaternal-fetal interfaceTrophoblast cellsIntrauterine infectionPregnancy complicationsNormal pregnancyImmune cellsImmune responseImmune systemHuman first trimester trophoblast cellsGrowth-related oncogene alphaCertain pregnancy complicationsElevated leukocyte infiltrationMaternal immune systemGrowth-related oncogeneTLR-3 stimulationImmune cell migrationSecretion of chemokinesInnate immune systemElevated monocytesPaternal AgsPreterm laborNK cellsTLR-3