2003
Glucocorticoid Enhances Transforming Growth Factor-β Effects on Extracellular Matrix Protein Expression in Human Placental Mesenchymal Cells1
Lee MJ, Ma Y, LaChapelle L, Kadner SS, Guller S. Glucocorticoid Enhances Transforming Growth Factor-β Effects on Extracellular Matrix Protein Expression in Human Placental Mesenchymal Cells1. Biology Of Reproduction 2003, 70: 1246-1252. PMID: 14681196, DOI: 10.1095/biolreprod.103.021956.Peer-Reviewed Original ResearchConceptsPlacental mesenchymal cellsIntrauterine growth restrictionFFN levelsProtein expressionCol IV expressionInteraction of glucocorticoidsDose-dependent mannerHuman term placentaFibronectin protein levelsExtracellular matrix protein expressionUncomplicated pregnanciesPolymerase chain reaction analysisReal-time polymerase chain reaction analysisGrowth restrictionDEX treatmentChain reaction analysisECM proteinsPlacental villiTerm placentaECM protein expressionCol IIIPlacental architectureMatrix protein expressionDexamethasoneGlucocorticoids
1994
Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta
Guller S, Markiewicz L, Wozniak R, Burnham J, Wang E, Kaplan P, Lockwood C. Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta. Endocrinology 1994, 134: 2064-2071. DOI: 10.1210/en.134.5.2064.Peer-Reviewed Original ResearchEffects of glucocorticoidsTerm cellsLevels of glucocorticoidsTrimester cellsDexamethasone treatmentTrimester of human pregnancyControl levelsGlucocorticoid responseSeparation of placentaTreatment of cytotrophoblastsLevels of hCGControl valuesIncreased glucocorticoid responseHuman first trimesterLow levels of glucocorticoidsGlucocorticoid-mediated effectsLevels of FN mRNARates of FNElevated levels of glucocorticoidsExtracellular matrix protein expressionLevels of FNCytotrophoblast culturesReduced glucocorticoid responsivenessHuman pregnancyFirst-trimester