2014
Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection
Peterson J, Gisslen M, Zetterberg H, Fuchs D, Shacklett BL, Hagberg L, Yiannoutsos CT, Spudich SS, Price RW. Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection. PLOS ONE 2014, 9: e116081. PMID: 25541953, PMCID: PMC4277428, DOI: 10.1371/journal.pone.0116081.Peer-Reviewed Original ResearchConceptsNeurofilament light chain proteinT-tau levelsNeuronal biomarkersViral suppressionHIV infectionPrimary infectionCentral nervous system HIV infectionCSF t-tau levelsCSF Aβ peptidesHIV disease progressionAge-adjusted normsSoluble amyloid precursorHierarchy of sensitivityBlood CD4CD4 50HAD patientsHAD subjectsCD4 declineNeuronal injuryCross-sectional designProgressive injuryHIV progressionCSF biomarkersCSF concentrationsDisease progression
2013
Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapy
Yilmaz A, Yiannoutsos CT, Fuchs D, Price RW, Crozier K, Hagberg L, Spudich S, Gisslén M. Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapy. Journal Of Neuroinflammation 2013, 10: 828. PMID: 23664008, PMCID: PMC3657550, DOI: 10.1186/1742-2094-10-62.Peer-Reviewed Original ResearchConceptsCSF neopterin levelsAntiretroviral therapyNeopterin levelsCerebrospinal fluidCSF neopterinHAD patientsMacrophage activationART-mediated viral suppressionCommencement of ARTHigher pre-ART levelsCSF neopterin concentrationsPre-ART levelsProlonged antiretroviral therapySuppressive antiretroviral therapySet-point levelsBlood neopterinHAD subjectsART initiationAsymptomatic HIVTreatment-naïveViral suppressionNeopterin concentrationsImmune activationMost HIVHIV