2023
Microbiota in disease-transmitting vectors
Wang J, Gao L, Aksoy S. Microbiota in disease-transmitting vectors. Nature Reviews Microbiology 2023, 21: 604-618. PMID: 37217793, DOI: 10.1038/s41579-023-00901-6.Peer-Reviewed Original ResearchConceptsSymbiotic associationVector-borne diseasesDisease-transmitting vectorsAlternative control methodsVector competenceUnique key featuresHealth of humansSymbiotic microorganismsVector taxaReproductive strategiesArthropod hostsLife historyVector arthropodsHaematophagous arthropodsTriatomine bugsBlood feedVector populationsTransmission successArthropodsFeeding behaviorCurrent knowledgeMicrobiotaPathogensKnowledge gapsTaxa
2019
Colonization of the tsetse fly midgut with commensal Kosakonia cowanii Zambiae inhibits trypanosome infection establishment
Weiss BL, Maltz MA, Vigneron A, Wu Y, Walter KS, O’Neill M, Wang J, Aksoy S. Colonization of the tsetse fly midgut with commensal Kosakonia cowanii Zambiae inhibits trypanosome infection establishment. PLOS Pathogens 2019, 15: e1007470. PMID: 30817773, PMCID: PMC6394900, DOI: 10.1371/journal.ppat.1007470.Peer-Reviewed Original ResearchConceptsRefractory phenotypeEnormous socio-economic burdenWild-type counterpartsInfection establishmentSocio-economic burdenMidgut environmentEntomopathogenic Serratia marcescensEndemic regionsPathogenic trypanosomesInfectionStable infectionAdverse effectsAnimal African trypanosomiasesVector competenceGutCurrent disease control strategiesSaharan AfricaDisease control strategiesSurvivalSerratia marcescensTsetse gutExogenous bacteriumFly survivalNovel strategyPhenotype
2016
Mammalian African trypanosome VSG coat enhances tsetse’s vector competence
Aksoy E, Vigneron A, Bing X, Zhao X, O'Neill M, Wu YN, Bangs JD, Weiss BL, Aksoy S. Mammalian African trypanosome VSG coat enhances tsetse’s vector competence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 6961-6966. PMID: 27185908, PMCID: PMC4922192, DOI: 10.1073/pnas.1600304113.Peer-Reviewed Original ResearchConceptsVariant surface glycoproteinPeritrophic matrixMammalian hostsVector competenceTranscription factor familyMidgut homeostasisTsetse midgutTrypanosome biologyFactor familyPM barrierCoat proteinNovel functionAfrican trypanosomesTsetse vectorInfection processParasite developmentAnimal trypanosomiasesAntigenic variationVSG moleculesVSG coatBiological vectorsMidgutProtozoan parasiteDisease transmissionTsetse flies
2007
Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing
Nayduch D, Aksoy S. Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing. Journal Of Medical Entomology 2007, 51 DOI: 10.1603/0022-2585(2007)44[660:ritfdg]2.0.co;2.Peer-Reviewed Original ResearchAttacin expressionTsetse fliesReverse geneticsRNA interferenceFly speciesGene expressionAttacinCertain speciesSusceptible speciesBlood feedingSpeciesVector competenceFliesImmune challengeEfficient vectorDevastating diseaseExpressionRefractory speciesTsetseG. pallidipesAfrican trypanosomiasisHumoral immune responseSalivary glandsRepressionDisease transmissionRefractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing
Nayduch D, Aksoy S. Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing. Journal Of Medical Entomology 2007, 44: 660-665. DOI: 10.1603/0022-2585%282007%2944%5b660%3aritfdg%5d2.0.co%3b2.Peer-Reviewed Original ResearchAttacin expressionTsetse fliesReverse geneticsRNA interferenceFly speciesGene expressionAttacinCertain speciesSusceptible speciesBlood feedingSpeciesVector competenceFliesImmune challengeEfficient vectorSusceptible fliesDevastating diseaseExpressionRefractory speciesTsetseG. pallidipesAfrican trypanosomiasisHumoral immune responseSalivary glandsRepression
2001
Prospects for control of African trypanosomiasis by tsetse vector manipulation
Aksoy S, O'Neill S, Maudlin I, Dale C, Robinson A. Prospects for control of African trypanosomiasis by tsetse vector manipulation. Trends In Parasitology 2001, 17: 29-35. PMID: 11137738, DOI: 10.1016/s1471-4922(00)01850-x.Peer-Reviewed Original ResearchConceptsArea-wide approachHuman disease managementLivestock ownersAnimal diseasesAgricultural outputMolecular genetic approachesImportant insectsInfected hostDisease managementEconomic incentivesTsetse populationsVector manipulationGenetic approachesMammalian hostsVector competenceEffective vaccineDiseases reliesHostTrypanosomiasisControl strategyInsectsAfrican trypanosomiasisTsetseLong runControl