2022
Microbe Profile: Wigglesworthia glossinidia: the tsetse fly’s significant other
Weiss BL, Rio RVM, Aksoy S. Microbe Profile: Wigglesworthia glossinidia: the tsetse fly’s significant other. Microbiology 2022, 168: 001242. PMID: 36129743, PMCID: PMC10723186, DOI: 10.1099/mic.0.001242.Peer-Reviewed Original ResearchConceptsPhysiological homeostasisNutritional roleEssential nutritional roleUnique physiological adaptationsTsetse fliesFly microbiotaWigglesworthia glossinidiaObligate mutualistsHost fitnessAncient associationParasitic trypanosomesLarval periodPhysiological adaptationsFitness outcomesTsetse's abilityAntimicrobial responsesImmune systemAmidasesFliesMicrobiotaMutualistsWigglesworthiaEndosymbiontsGenomeB vitamins
2012
PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring
Wang J, Aksoy S. PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 10552-10557. PMID: 22689989, PMCID: PMC3387098, DOI: 10.1073/pnas.1116431109.Peer-Reviewed Original ResearchConceptsMother's milkImmune deficiency (IMD) pathwayPGRP-LBHost immune systemImmune system developmentIntrauterine environmentNutritional supplementationDietary supplementationHyperimmune responseImmune systemImpact immunityNewborn progenyParasite infectionAdultsParasitized adultsPeptidoglycan recognition proteinsSuch adultsImmunitySupplementationAntitrypanosomal activityPivotal roleMilkInductionHost fecundityMilk proteinsObligate Symbionts Activate Immune System Development in the Tsetse Fly
Weiss BL, Maltz M, Aksoy S. Obligate Symbionts Activate Immune System Development in the Tsetse Fly. The Journal Of Immunology 2012, 188: 3395-3403. PMID: 22368278, PMCID: PMC3311772, DOI: 10.4049/jimmunol.1103691.Peer-Reviewed Original ResearchConceptsSymbiotic bacteriaImmune system developmentNovel evolutionary adaptationImmunity-related genesObligate symbiontsSymbiotic microbesObligate mutualistsViviparous modeProper immune system functionEvolutionary adaptationPhagocytic hemocytesMolecular mechanismsCell extractsMolecular componentsSusceptible phenotypeNonpathogenic Escherichia coliEscherichia coliTsetse fliesImmune systemFliesAtypical expressionHemocytesImmune system functionPhenotypeTsetse
2001
Tsetse immune responses and trypanosome transmission: Implications for the development of tsetse-based strategies to reduce trypanosomiasis
Hao Z, Kasumba I, Lehane M, Gibson W, Kwon J, Aksoy S. Tsetse immune responses and trypanosome transmission: Implications for the development of tsetse-based strategies to reduce trypanosomiasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12648-12653. PMID: 11592981, PMCID: PMC60108, DOI: 10.1073/pnas.221363798.Peer-Reviewed Original ResearchConceptsFat bodyInsect immune systemAntimicrobial peptide genesFat body tissueImmune responsive genesDifferent life stagesTransgenic approachesResponsive genesAntimicrobial genesImmune responseSubtractive cloningPeptide genesAfrican trypanosomesMolecular signalsImmune systemDifferential regulationInfection processLife stagesTrypanosome transmissionParasite transmissionGenesImportant vectorEscherichia coliBiochemical natureDiptericin