2022
Microbe Profile: Wigglesworthia glossinidia: the tsetse fly’s significant other
Weiss BL, Rio RVM, Aksoy S. Microbe Profile: Wigglesworthia glossinidia: the tsetse fly’s significant other. Microbiology 2022, 168: 001242. PMID: 36129743, PMCID: PMC10723186, DOI: 10.1099/mic.0.001242.Peer-Reviewed Original ResearchConceptsPhysiological homeostasisNutritional roleEssential nutritional roleUnique physiological adaptationsTsetse fliesFly microbiotaWigglesworthia glossinidiaObligate mutualistsHost fitnessAncient associationParasitic trypanosomesLarval periodPhysiological adaptationsFitness outcomesTsetse's abilityAntimicrobial responsesImmune systemAmidasesFliesMicrobiotaMutualistsWigglesworthiaEndosymbiontsGenomeB vitamins
2021
A machine learning approach to integrating genetic and ecological data in tsetse flies (Glossina pallidipes) for spatially explicit vector control planning
Bishop AP, Amatulli G, Hyseni C, Pless E, Bateta R, Okeyo WA, Mireji PO, Okoth S, Malele I, Murilla G, Aksoy S, Caccone A, Saarman NP. A machine learning approach to integrating genetic and ecological data in tsetse flies (Glossina pallidipes) for spatially explicit vector control planning. Evolutionary Applications 2021, 14: 1762-1777. PMID: 34295362, PMCID: PMC8288027, DOI: 10.1111/eva.13237.Peer-Reviewed Original ResearchGenetic dataVectors of humanLake Victoria basinAnimal African trypanosomiasisGenetic connectivityVector-borne disease transmissionFuture monitoring effortsMicrosatellite lociHabitat useImportant environmental predictorsHabitat suitabilityFuture climatic changesDispersal patternsVictoria basinEcological dataEnvironmental predictorsVector systemTsetse fliesTsetse speciesClimatic shiftsFliesClimatic changesSampling sitesMonitoring effortsVector control
2014
Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis
Initiative I, Attardo G, Abila P, Auma J, Baumann A, Benoit J, Brelsfoard C, Ribeiro J, Cotton J, Pham D, Darby A, Van Den Abbeele J, Denlinger D, Field L, Nyanjom S, Gaunt M, Geiser D, Gomulski L, Haines L, Hansen I, Jones J, Kibet C, Kinyua J, Larkin D, Lehane M, Rio R, Macdonald S, Macharia R, Malacrida A, Marco H, Marucha K, Masiga D, Meuti M, Mireji P, Obiero G, Koekemoer J, Okoro C, Omedo I, Osamor V, Balyeidhusa A, Peyton J, Price D, Quail M, Ramphul U, Rawlings N, Riehle M, Robertson H, Sanders M, Scott M, Dashti Z, Snyder A, Srivastava T, Stanley E, Swain M, Hughes D, Tarone A, Taylor T, Telleria E, Thomas G, Walshe D, Wilson R, Winzerling J, Acosta-Serrano A, Aksoy S, Arensburger P, Aslett M, Bateta R, Benkahla A, Berriman M, Bourtzis K, Caers J, Caljon G, Christoffels A, Falchetto M, Friedrich M, Fu S, Gäde G, Githinji G, Gregory R, Hall N, Harkins G, Hattori M, Hertz-Fowler C, Hide W, Hu W, Imanishi T, Inoue N, Jonas M, Kawahara Y, Koffi M, Kruger A, Lawson D, Lehane S, Lehväslaiho H, Luiz T, Makgamathe M, Malele I, Manangwa O, Manga L, Megy K, Michalkova V, Mpondo F, Mramba F, Msangi A, Mulder N, Murilla G, Mwangi S, Okedi L, Ommeh S, Ooi C, Ouma J, Panji S, Ravel S, Rose C, Sakate R, Schoofs L, Scolari F, Sharma V, Sim C, Siwo G, Solano P, Stephens D, Suzuki Y, Sze S, Touré Y, Toyoda A, Tsiamis G, Tu Z, Wamalwa M, Wamwiri F, Wang J, Warren W, Watanabe J, Weiss B, Willis J, Wincker P, Zhang Q, Zhou J. Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis. Science 2014, 344: 380-386. PMID: 24763584, PMCID: PMC4077534, DOI: 10.1126/science.1249656.Peer-Reviewed Original ResearchConceptsGenome sequenceLactation-specific proteinsProtein-encoding genesBacterial genome sequencesPathogen recognition proteinsTsetse fliesMicrobial symbiosesTsetse biologyViviparous reproductionGenome dataRecognition proteinsSole vectorsChromosomal integrationDisease vectorsAfrican trypanosomiasisGenomeGenesFliesProteinSequenceMultiple aspectsHuman African trypanosomiasisImportant insightsMultiple discoveriesSymbioses
2012
Obligate Symbionts Activate Immune System Development in the Tsetse Fly
Weiss BL, Maltz M, Aksoy S. Obligate Symbionts Activate Immune System Development in the Tsetse Fly. The Journal Of Immunology 2012, 188: 3395-3403. PMID: 22368278, PMCID: PMC3311772, DOI: 10.4049/jimmunol.1103691.Peer-Reviewed Original ResearchConceptsSymbiotic bacteriaImmune system developmentNovel evolutionary adaptationImmunity-related genesObligate symbiontsSymbiotic microbesObligate mutualistsViviparous modeProper immune system functionEvolutionary adaptationPhagocytic hemocytesMolecular mechanismsCell extractsMolecular componentsSusceptible phenotypeNonpathogenic Escherichia coliEscherichia coliTsetse fliesImmune systemFliesAtypical expressionHemocytesImmune system functionPhenotypeTsetse
2011
Tsetse Immune System Maturation Requires the Presence of Obligate Symbionts in Larvae
Weiss BL, Wang J, Aksoy S. Tsetse Immune System Maturation Requires the Presence of Obligate Symbionts in Larvae. PLOS Biology 2011, 9: e1000619. PMID: 21655301, PMCID: PMC3104962, DOI: 10.1371/journal.pbio.1000619.Peer-Reviewed Original ResearchConceptsIntrauterine larvaeBeneficial microbial symbiontsSpecific host phenotypesMilk gland secretionsHost physiological processesCo-evolutionary adaptationMicrobial symbiontsWigglesworthia glossinidiaObligate mutualistsHost phenotypePhysiological processesImmune system homeostasisWigglesworthiaTsetse fliesImportant functionsGland secretionSystem homeostasisFliesGlossina morsitansMutualistsSymbiontsDietary supplementationLarvaeHomeostasisPhenotype
2007
Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing
Nayduch D, Aksoy S. Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing. Journal Of Medical Entomology 2007, 51 DOI: 10.1603/0022-2585(2007)44[660:ritfdg]2.0.co;2.Peer-Reviewed Original ResearchAttacin expressionTsetse fliesReverse geneticsRNA interferenceFly speciesGene expressionAttacinCertain speciesSusceptible speciesBlood feedingSpeciesVector competenceFliesImmune challengeEfficient vectorDevastating diseaseExpressionRefractory speciesTsetseG. pallidipesAfrican trypanosomiasisHumoral immune responseSalivary glandsRepressionDisease transmissionRefractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing
Nayduch D, Aksoy S. Refractoriness in Tsetse Flies (Diptera: Glossinidae) May be a Matter of Timing. Journal Of Medical Entomology 2007, 44: 660-665. DOI: 10.1603/0022-2585%282007%2944%5b660%3aritfdg%5d2.0.co%3b2.Peer-Reviewed Original ResearchAttacin expressionTsetse fliesReverse geneticsRNA interferenceFly speciesGene expressionAttacinCertain speciesSusceptible speciesBlood feedingSpeciesVector competenceFliesImmune challengeEfficient vectorSusceptible fliesDevastating diseaseExpressionRefractory speciesTsetseG. pallidipesAfrican trypanosomiasisHumoral immune responseSalivary glandsRepression
2001
Microsatellite Polymorphism in Tsetse Flies (Diptera: Glossinidae)
Luna C, Bonizzoni M, Cheng Q, Robinson A, Aksoy S, Zheng L. Microsatellite Polymorphism in Tsetse Flies (Diptera: Glossinidae). Journal Of Medical Entomology 2001, 38: 376-381. PMID: 11372961, DOI: 10.1603/0022-2585-38.3.376.Peer-Reviewed Original ResearchConceptsTsetse fliesCertain wild populationsPolymorphic microsatellite lociVectors of trypanosomesG. austeni NewsteadWild populationsMicrosatellite lociIntraspecific variationGenetic variabilityMicrosatellite markersField populationsSubpopulation structureVectorial capacityLociFliesMicrosatellite polymorphismCausative agent
1999
Phytogeny of genusGlossina (Diptera:Glossinidae) according to ITS2 sequences
Chen X, Li S, Li C, Zhao S, Serap A. Phytogeny of genusGlossina (Diptera:Glossinidae) according to ITS2 sequences. Science China Life Sciences 1999, 42: 249-258. PMID: 20229338, DOI: 10.1007/bf03183600.Peer-Reviewed Original Research
1993
Phylogenetically distant symbiotic microorganisms reside in Glossina midgut and ovary tissues
O'NEILL S, GOODING R, AKSOY S. Phylogenetically distant symbiotic microorganisms reside in Glossina midgut and ovary tissues. Medical And Veterinary Entomology 1993, 7: 377-383. PMID: 8268495, DOI: 10.1111/j.1365-2915.1993.tb00709.x.Peer-Reviewed Original ResearchConceptsIntracellular bacterial symbiontsBlood-feeding insectsDNA oligonucleotide primersBacterial symbiontsSymbiotic microorganismsAlpha subdivisionSymbiotic bacteriaGamma subdivisionGenus WolbachiaGlossina speciesPolymerase chain reactionOvary tissuesOligonucleotide primersTsetse fliesMidgutSpeciesSymbiontsInsectsWolbachiaProteobacteriaSubspeciesChain reactionFliesMicroorganismsTissue