Scott Woods, MD
Professor of PsychiatryCards
Appointments
Psychiatry
Primary
Child Study Center
Secondary
Contact Info
About
Titles
Professor of Psychiatry
Biography
Dr. Woods assesses young people at risk for psychosis through his PRIME Clinic, which also offers studies aiming to improve treatment for current symptoms and preventing progression.
Appointments
Psychiatry
ProfessorPrimaryChild Study Center
ProfessorSecondary
Other Departments & Organizations
- Adult Psychiatry
- Child Study Center
- Connecticut Mental Health Center
- MR Center
- PRIME Psychosis Prodrome Research Clinic
- Psychiatry
- Yale Medicine
- Yale Ventures
Education & Training
- Resident
- Massachusetts General Hospital (1984)
- MD
- Baylor College of Medicine (1978)
Research
Overview
Predictors and Mechanisms of Conversion to Psychosis (MH082022)
Aspirin vs placebo for the psychosis prodrome
D-serine for the psychosis prodrome (MH074356)
Dutetrabenzine for tardive dyskinesia
Huperzine for cognitive enhancement in schizophrenia (MH083436)
Medical Subject Headings (MeSH)
Adolescent Psychiatry; Prodromal Symptoms; Psychiatry; Psychotic Disorders
ORCID
0000-0002-3103-5228
Research at a Glance
Yale Co-Authors
Frequent collaborators of Scott Woods's published research.
Publications Timeline
A big-picture view of Scott Woods's research output by year.
Research Interests
Research topics Scott Woods is interested in exploring.
Tyrone Cannon
Albert Powers, MD, PhD
Vinod H. Srihari, MD
Maria Ferrara, MD
Carolyn Fredericks, MD
Melissa C Funaro, MLS, MS
31Publications
163Citations
Psychotic Disorders
Prodromal Symptoms
Publications
2024
Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons
Ku B, Yuan Q, Haardörfer R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Druss B, Walker E, Anglin D. Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons. Psychiatry Research 2024, 342: 116222. PMID: 39378539, DOI: 10.1016/j.psychres.2024.116222.Peer-Reviewed Original ResearchAltmetricConceptsHealthy comparisonPositive symptomsCHR-PPeer victimizationNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsAttenuated positive symptomsPositive psychotic symptomsClinical high riskFewer life eventsAssociated with schizophreniaEthnoracial diversityPsychotic symptomsHigh riskPrevent psychosisDepressive symptomsStructural equation modelingLife eventsProdromal symptomsPsychosisDiscriminatory experiencesEthnoracial minoritiesSocial determinantsNeighborhood povertyEthnoracial groupsImpact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis
Giampetruzzi E, Walker E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, LoPilato A. Impact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis. Psychiatry Research 2024, 342: 116214. PMID: 39368239, DOI: 10.1016/j.psychres.2024.116214.Peer-Reviewed Original ResearchAltmetricConceptsAdverse childhood experiencesClinical high riskEffects of protective factorsInternalizing disordersDepressive disorderCHR-PEmotional neglectSelf-harm/suicideProtective factorsChildhood experiencesHigher levels of adverse childhood experiencesHistory of depressive disorderSexual abuseLevels of adverse childhood experiencesInternalizing psychiatric disordersChildhood sexual abusePresence of protective factorsImpact of adverse childhood experiencesAnxiety disordersAdministered measuresPsychiatric diagnosisPsychiatric disordersPsychiatric outcomesChild adversitySubstance useBeyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis
Deng W, Chong B, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39260565, DOI: 10.1016/j.bpsc.2024.08.020.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PTrajectory groupsMaintenance of symptomsOnset of psychosisNon-convertersHealthy controlsDiagnostic constructSymptom trajectoriesPsychosisAffective comorbiditiesAssess symptomsHeightened riskFunctional impairmentSymptomsEtiological risk factorsFunctional outcomesImminent onsetLevels of intensityRemissionRisk factorsIndividualsPhase 3DistressImpairmentA computational account of the development and evolution of psychotic symptoms.
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A computational account of the development and evolution of psychotic symptoms. Biological Psychiatry 2024 PMID: 39260466, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchConceptsPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityDiminished signal-to-noise ratioComputational accountPsychiatric interventionNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formationSleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis
Cohen S, Goldsmith D, Ning C, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Woods S, Walker E, Miller B. Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis. Psychiatry Research 2024, 341: 116147. PMID: 39197223, DOI: 10.1016/j.psychres.2024.116147.Peer-Reviewed Original ResearchAltmetricConceptsPsychosis-risk symptomsClinical high riskSuicidal ideationCHR-P individualsCHR-PSleep disturbanceTerminal insomniaNorth American Prodrome Longitudinal StudyAssociated with conversion to psychosisSleep problemsConversion to psychosisTreatment of sleep disturbancesAssociated with SIIndices of sleep disturbanceMultiple indicesPsychosisIdeationLongitudinal intervention studyInsomniaLongitudinal studySchizophreniaSymptomsSleepSymptom scoresInvestigate relationshipsOccasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts
Kennedy L, Ku B, Addington J, Amir C, Bearden C, Cannon T, Carrión R, Cornblatt B, Keshavan M, Perkins D, Mathalon D, Stone W, Walker E, Woods S, Cadenhead K. Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts. Schizophrenia Research 2024, 271: 319-331. PMID: 39084107, DOI: 10.1016/j.schres.2024.07.032.Peer-Reviewed Original ResearchConceptsClinical high riskCannabis use frequencyPremorbid functioningCannabis usePsychosis cohortSocial functioningCannabis usersAssociated with greater symptom severityAssociated with better neurocognitionNorth American Prodrome Longitudinal StudyClinical high-risk participantsClinical high-risk youthClinical high-risk populationsUse groupRates of cannabis useCannabis use groupsMeasures of IQCannabis use patternsGreater symptom severityHigher premorbid functioningFollow-up analysisPsychosis sampleHigher IQNeurocognitive domainsFirst-episodeRobust Brain Correlates of Cognitive Performance in Psychosis and its Prodrome
Ward H, Beermann A, Xie J, Yildiz G, Felix K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Coleman M, Bouix S, Holt D, Öngür D, Breier A, Shenton M, Heckers S, Halko M, Lewandowski K, Brady R. Robust Brain Correlates of Cognitive Performance in Psychosis and its Prodrome. Biological Psychiatry 2024 PMID: 39032726, DOI: 10.1016/j.biopsych.2024.07.012.Peer-Reviewed Original ResearchAltmetricConceptsAuditory continuous performance taskConnectome-wide association studiesEarly psychosisCognitive performanceNorth American Prodrome Longitudinal Study 2At-risk individualsCorrelates of cognitive performanceBrain-cognition relationshipsBrain-phenotype relationshipsBrain-behavior associationsContinuous performance taskEarly-course psychosisLongitudinal Study 2Resting-state fMRIProspective study of individualsHuman Connectome ProjectPsychosis onsetStudy of individualsPsychosisStudy 2Performance tasksNeurocognitive impairmentCognitive instrumentsHealthy participantsRobust associationsSex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis
Chintoh A, Liu L, Braun A, Akseer S, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, McGlashan T, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Addington J. Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis. Schizophrenia Research 2024, 271: 153-160. PMID: 39029145, DOI: 10.1016/j.schres.2024.07.030.Peer-Reviewed Original ResearchAltmetricConceptsClinical high riskClinical high-risk individualsSex differencesNegative symptomsTransition to psychosisInvestigate sex differencesNo sex differencesSchizophreniform disorderCHR individualsPsychosisSubstance useSchizophreniaSymptomsHigh riskIndividualsSchizophreniformAnxietyClinical presentationSexDepressionDisordersBaselineDifferencesMaleYouthNeurocognition in adolescents and young adults at clinical high risk for psychosis: Predictive stability for social and role functioning
Carrión R, Ku B, Dorvil S, Auther A, McLaughlin D, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cornblatt B. Neurocognition in adolescents and young adults at clinical high risk for psychosis: Predictive stability for social and role functioning. Schizophrenia Research 2024, 271: 129-137. PMID: 39024961, DOI: 10.1016/j.schres.2024.06.054.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PNeurocognitive deficitsImpact of processing speedProcessing speedNorth American Prodrome Longitudinal StudyBaseline processing speedCHR-P participantsPoor social functioningCHR-P individualsYoung adultsDisorganized symptomsBaseline neurocognitionAttentional impairmentAttention deficitDevelopmental trajectoriesNeurocognitionPsychosisImpact of symptomsProdromal phaseSocial functioningIntervention issuesTreatment targetLongitudinal studyDeficitsThe Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program
Ferrara M, Basaldella M, Vacca F, Woods S, Walsh B, Cannon T, Srihari V, Grassi L. The Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program. Early Intervention In Psychiatry 2024 PMID: 38769052, DOI: 10.1111/eip.13548.Peer-Reviewed Original ResearchConceptsClinical high riskFirst-episode psychosisDSM-5-Attenuated Psychosis SyndromeItalian adaptationPsychosis syndromeDSM-5FEP programsEarly stages of psychosisItalian versionFirst-episode psychosis servicesFull-blown psychosisStages of psychosisEpisode of psychosisClinical structured interviewEpisode psychosisEstablished psychosisTrained psychologistsPsychiatric historyPsychosisPsychosis servicesHigh riskStructured interviewsClinical settingEarly detection of individualsAssess validity
Clinical Trials
Current Trials
ProNET
HIC ID2000029159RolePrincipal InvestigatorPrimary Completion Date12/31/2024Recruiting ParticipantsStudy of Brain Function Across the Lifespan
HIC ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 yearsSleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
HIC ID1201009524RoleSub InvestigatorPrimary Completion Date01/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
News
News
- September 07, 2022
PRIME Clinic Receives Four Additional Years of SAMHSA Funding
- February 14, 2022
Yale Department of Psychiatry #2 in Psychiatric Research Funding
- June 08, 2021
Caring for young people's mental health at PRIME
- September 16, 2020
Yale Researchers to Lead $52M Investigation Into Cause, Effect of Schizophrenia in Some High-risk Adolescents
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Mailing Address
Psychiatry
300 George St
New Haven, CT 06511-
United States