2022
Microenvironmental sensing by fibroblasts controls macrophage population size
Zhou X, Franklin RA, Adler M, Carter TS, Condiff E, Adams TS, Pope SD, Philip NH, Meizlish ML, Kaminski N, Medzhitov R. Microenvironmental sensing by fibroblasts controls macrophage population size. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2205360119. PMID: 35930670, PMCID: PMC9371703, DOI: 10.1073/pnas.2205360119.Peer-Reviewed Original ResearchConceptsCell typesDensity-dependent gene expressionTGF-β target genesDiverse cell typesActin-dependent mechanismLineage-specific growth factorsDistinct cell typesGrowth factor availabilityActivation of YAP1Different cell typesExpression programsMicroenvironmental sensingTranscriptional coactivatorTarget genesGene expressionPopulation sizeFactor availabilityPopulation numbersTissue environmentTissue integrityHippoProliferation of macrophagesYAP1Animal tissuesMechanical forcesActivation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs
Eisenstein A, Hilliard BK, Pope SD, Zhang C, Taskar P, Waizman DA, Israni-Winger K, Tian H, Luan HH, Wang A. Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs. Immunity 2022, 55: 1082-1095.e5. PMID: 35588739, PMCID: PMC9205175, DOI: 10.1016/j.immuni.2022.04.015.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsAnti-inflammatory propertiesMyeloid cellsPrescription nonsteroidal anti-inflammatory drugsGrowth/differentiation factor 15Anti-inflammatory effectsDifferentiation factor 15Myeloid-specific deletionAnti-inflammatory activityAnti-inflammatory drugsNrf2-dependent mechanismKelch-like ECHTranscription factor Nrf2NSAID usageClinical outcomesCOX inhibitionPharmacologic approachesFactor 15Murine modelTissue protectionMurine myeloid cellsNuclear factorPrimary humanFactor Nrf2Nrf2
2021
γδ T cells regulate the intestinal response to nutrient sensing
Sullivan ZA, Khoury-Hanold W, Lim J, Smillie C, Biton M, Reis BS, Zwick RK, Pope SD, Israni-Winger K, Parsa R, Philip NH, Rashed S, Palm N, Wang A, Mucida D, Regev A, Medzhitov R. γδ T cells regulate the intestinal response to nutrient sensing. Science 2021, 371 PMID: 33737460, DOI: 10.1126/science.aba8310.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCell CommunicationDietary CarbohydratesDietary ProteinsDigestionEnterocytesGene Expression RegulationInterleukinsIntestinal AbsorptionIntestinal MucosaIntestine, SmallMice, Inbred C57BLNutrientsReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTranscription, GeneticTranscriptomeConceptsNutrient sensingNutrient uptakeEpithelial gene expressionTranscriptional responseNutrient availabilityGene expressionCellular remodelingΓδ T cellsCarbohydrate availabilityEpithelial compartmentBarrier defenseTissue localizationT cellsCellsCarbohydrate digestionType 3 innate lymphoid cellsTranscriptomeEffect of dietMachineryInnate lymphoid cellsDirect encountersTransportersUptakeLymphoid cellsEnzyme