γδ T cells regulate the intestinal response to nutrient sensing
Sullivan ZA, Khoury-Hanold W, Lim J, Smillie C, Biton M, Reis BS, Zwick RK, Pope SD, Israni-Winger K, Parsa R, Philip NH, Rashed S, Palm N, Wang A, Mucida D, Regev A, Medzhitov R. γδ T cells regulate the intestinal response to nutrient sensing. Science 2021, 371 PMID: 33737460, DOI: 10.1126/science.aba8310.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCell CommunicationDietary CarbohydratesDietary ProteinsDigestionEnterocytesGene Expression RegulationInterleukinsIntestinal AbsorptionIntestinal MucosaIntestine, SmallMice, Inbred C57BLNutrientsReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTranscription, GeneticTranscriptomeConceptsNutrient sensingNutrient uptakeEpithelial gene expressionTranscriptional responseNutrient availabilityGene expressionCellular remodelingΓδ T cellsCarbohydrate availabilityEpithelial compartmentBarrier defenseTissue localizationT cellsCellsCarbohydrate digestionType 3 innate lymphoid cellsTranscriptomeEffect of dietMachineryInnate lymphoid cellsDirect encountersTransportersUptakeLymphoid cellsEnzyme