2022
Microenvironmental sensing by fibroblasts controls macrophage population size
Zhou X, Franklin RA, Adler M, Carter TS, Condiff E, Adams TS, Pope SD, Philip NH, Meizlish ML, Kaminski N, Medzhitov R. Microenvironmental sensing by fibroblasts controls macrophage population size. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2205360119. PMID: 35930670, PMCID: PMC9371703, DOI: 10.1073/pnas.2205360119.Peer-Reviewed Original ResearchConceptsCell typesDensity-dependent gene expressionTGF-β target genesDiverse cell typesActin-dependent mechanismLineage-specific growth factorsDistinct cell typesGrowth factor availabilityActivation of YAP1Different cell typesExpression programsMicroenvironmental sensingTranscriptional coactivatorTarget genesGene expressionPopulation sizeFactor availabilityPopulation numbersTissue environmentTissue integrityHippoProliferation of macrophagesYAP1Animal tissuesMechanical forces
2021
γδ T cells regulate the intestinal response to nutrient sensing
Sullivan ZA, Khoury-Hanold W, Lim J, Smillie C, Biton M, Reis BS, Zwick RK, Pope SD, Israni-Winger K, Parsa R, Philip NH, Rashed S, Palm N, Wang A, Mucida D, Regev A, Medzhitov R. γδ T cells regulate the intestinal response to nutrient sensing. Science 2021, 371 PMID: 33737460, DOI: 10.1126/science.aba8310.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCell CommunicationDietary CarbohydratesDietary ProteinsDigestionEnterocytesGene Expression RegulationInterleukinsIntestinal AbsorptionIntestinal MucosaIntestine, SmallMice, Inbred C57BLNutrientsReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTranscription, GeneticTranscriptomeConceptsNutrient sensingNutrient uptakeEpithelial gene expressionTranscriptional responseNutrient availabilityGene expressionCellular remodelingΓδ T cellsCarbohydrate availabilityEpithelial compartmentBarrier defenseTissue localizationT cellsCellsCarbohydrate digestionType 3 innate lymphoid cellsTranscriptomeEffect of dietMachineryInnate lymphoid cellsDirect encountersTransportersUptakeLymphoid cellsEnzyme