2023
Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection
Chaguza C, Hahn A, Petrone M, Zhou S, Ferguson D, Breban M, Pham K, Peña-Hernández M, Castaldi C, Hill V, Initiative Y, Billig K, Earnest R, Fauver J, Kalinch C, Kerantzas N, Koch T, De Kumar B, Landry M, Ott I, Peaper D, Tikhonova I, Vogels C, Schulz W, Swanstrom R, Roberts S, Grubaugh N. Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection. Cell Reports Medicine 2023, 4: 100943. PMID: 36791724, PMCID: PMC9906997, DOI: 10.1016/j.xcrm.2023.100943.Peer-Reviewed Original ResearchConceptsChronic infectionEvolutionary ratesGenetic diversityIntrahost evolutionDistinct genotypesHigher viral genome copiesVirus evolutionary ratesSARS-CoV-2 evolutionUntreated chronic infectionAdvantageous mutationsNucleotide substitutionsViral genome copiesDivergent variantsInfection hypothesisVariant emergenceViral populationsInfectious virusInfectionHallmark changesGenome copiesDifferent genotypesDiversityGenotypesTemporal dynamicsEvolutionMpox and Sexually Transmitted Infection Testing in the Outpatient Primary Care Setting—Why LGBTQ Health Is Global Health
Ilagan-Ying Y, Fisher A, Zimmerman A, Pellegrino A, Roberts S. Mpox and Sexually Transmitted Infection Testing in the Outpatient Primary Care Setting—Why LGBTQ Health Is Global Health. Journal Of General Internal Medicine 2023, 38: 1067-1071. PMID: 36633799, PMCID: PMC10039215, DOI: 10.1007/s11606-022-07988-2.Peer-Reviewed Original ResearchAnalysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center
Roberts S, Faruq R, Wilkinson A, Pashankar D, Russi M, Khokhar B, Martinello R. Analysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center. JAMA Internal Medicine 2023, 183: 84-86. PMID: 36441528, PMCID: PMC9706395, DOI: 10.1001/jamainternmed.2022.5426.Peer-Reviewed Original Research
2022
Disinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey Study
Roberts S, Havill N, Flores RM, Hendrix C, Williams MJ, Feinn RS, Choi SJ, Martinello RA, Marks AM, Murray TS. Disinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey Study. Journal Of Medical Internet Research 2022, 24: e42332. PMID: 36269222, PMCID: PMC9756115, DOI: 10.2196/42332.Peer-Reviewed Original ResearchMyometritis with pelvic septic vein thrombophlebitis secondary to Fusobacterium necrophorum sepsis
Koshy KM, Malik W, Roberts SC. Myometritis with pelvic septic vein thrombophlebitis secondary to Fusobacterium necrophorum sepsis. BMJ Case Reports 2022, 15: e250097. PMID: 36229077, PMCID: PMC9562719, DOI: 10.1136/bcr-2022-250097.Peer-Reviewed Original ResearchConceptsFusobacterium necrophorum sepsisRight gonadal veinAppropriate antibiotic therapyRight iliac veinIntrauterine device placementTargeted antimicrobial therapySeptic thrombophlebitisAbdominal painAntibiotic therapySeptic shockGonadal veinIliac veinVaginal dischargeAntimicrobial therapyBlood culturesMedical abortionYoung womenDevice placementThrombophlebitisFeverTherapyVeinSubsequent evaluationDefervesceSepsisHyperammonemia in lung transplantation: recognizing the gaps of our knowledge
Lum JM, Roberts SC. Hyperammonemia in lung transplantation: recognizing the gaps of our knowledge. Transplant Infectious Disease 2022, 24: e13937. PMID: 35989541, DOI: 10.1111/tid.13937.Peer-Reviewed Original ResearchHyperammonemia syndrome in immunosuppressed individuals
Roberts SC, Malik W, Ison MG. Hyperammonemia syndrome in immunosuppressed individuals. Current Opinion In Infectious Diseases 2022, 35: 262-268. PMID: 35665721, PMCID: PMC9179651, DOI: 10.1097/qco.0000000000000828.Peer-Reviewed Original ResearchConceptsLung transplant recipientsHyperammonemia syndromeUreaplasma sppTransplant recipientsImmunosuppressed individualsSolid organ transplant populationLung transplant donorsOrgan transplant populationPeri-transplant periodAppropriate antimicrobial therapyUrease-producing organismsHigh mortality rateTransplant populationTransplant donorsClinical manifestationsFatal conditionAntimicrobial therapySurveillance studyMortality rateSystemic infectionSyndromeDonor colonizationAntibiotic resistanceRapid diagnosticsRecipientsA mixed-methods evaluation on the efficacy and perceptions of needleless connector disinfectants
Roberts SC, Hendrix CA, Edwards LM, Feinn RS, Martinello RA, Murray TS. A mixed-methods evaluation on the efficacy and perceptions of needleless connector disinfectants. Infection Control And Hospital Epidemiology 2022, 44: 230-233. PMID: 35387702, PMCID: PMC9929708, DOI: 10.1017/ice.2022.72.Peer-Reviewed Original ResearchConceptsNeedleless connectorsMixed-methods evaluationNursing staffOverall bacterial burdenBloodstream infection preventionAcademic tertiary hospitalIsopropyl alcohol wipesSterile water controlTertiary hospitalNursing assessmentBacterial burdenInfection preventionImproved complianceStaff complianceChlorhexidine gluconateScrub timeConvenience sampleAlcohol wipesStaphylococcus epidermidisEfficacyProduct efficacyDry timeWipesDisinfection practicesComplianceAn outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era
Roberts SC, Palacios C, Grubaugh ND, Alpert T, Ott IM, Breban MI, Initiative Y, Martinello RA, Smith C, Davis MW, Mcmanus D, Tirmizi S, Topal JE, Azar MM, Malinis M. An outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era. Transplant Infectious Disease 2022, 24: e13782. PMID: 34969164, DOI: 10.1111/tid.13782.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Infection prevention practicesSARS-CoV-2 outbreakTransplant unitCOVID-19-associated morbiditySolid organ transplant recipientsSARS-CoV-2 vaccinationPrevention practicesHospital day 18Potential index casesOrgan transplant recipientsInfection prevention behaviorsMonoclonal antibody therapyCOVID-19SARS-CoV-2 clustersHospital staff membersWhole-genome sequencingAsymptomatic patientsTransplant recipientsPositive patientsAtypical presentationImmunocompromised patientsAntibody therapyVaccination eraDisease progression
2021
Colonization with Multidrug-resistant Organisms in Patients with Ventricular Assist Devices
Roberts SC, Nam HH, Kumar RN, Wu T, Harap RS, Pham DT, Rich JD, Stosor V. Colonization with Multidrug-resistant Organisms in Patients with Ventricular Assist Devices. ASAIO Journal 2021, 68: 1048-1053. PMID: 34967790, DOI: 10.1097/mat.0000000000001634.Peer-Reviewed Original ResearchConceptsMultidrug-resistant organismsVentricular assist deviceMDRO colonizationVAD infectionsVAD supportAssist deviceMethicillin-resistant Staphylococcus aureusVancomycin-resistant Enterococcus speciesVAD implantationLeading causeVAD recipientsPatientsInfectionEnterococcus speciesFurther studiesStaphylococcus aureusBest management strategyImplantationRiskNegative bacteriaMorbidityCohortMortalityImpact of colonizationColonizationCorrelation of healthcare worker vaccination with inpatient healthcare-associated coronavirus disease 2019 (COVID-19)
Roberts SC, Aniskiewicz MJ, Choi SJ, Pettker CM, Martinello RA. Correlation of healthcare worker vaccination with inpatient healthcare-associated coronavirus disease 2019 (COVID-19). Infection Control And Hospital Epidemiology 2021, 43: 524-525. PMID: 34544506, PMCID: PMC8485009, DOI: 10.1017/ice.2021.414.Peer-Reviewed Original ResearchUtility of Mass SARS-CoV-2 Testing of Asymptomatic Patients Before Ambulatory and Inpatient Preplanned Procedures Requiring Moderate Sedation or General Anesthesia
Roberts SC, Peaper DR, Sussman LS, Martinello RA, Pettker CM. Utility of Mass SARS-CoV-2 Testing of Asymptomatic Patients Before Ambulatory and Inpatient Preplanned Procedures Requiring Moderate Sedation or General Anesthesia. JAMA Network Open 2021, 4: e2114526. PMID: 34170307, PMCID: PMC8233702, DOI: 10.1001/jamanetworkopen.2021.14526.Peer-Reviewed Original ResearchGenetic Evaluation of Nosocomial Candida auris Transmission
Roberts SC, Zembower TR, Ozer EA, Qi C. Genetic Evaluation of Nosocomial Candida auris Transmission. Journal Of Clinical Microbiology 2021, 59: 10.1128/jcm.02252-20. PMID: 33472901, PMCID: PMC8092739, DOI: 10.1128/jcm.02252-20.Peer-Reviewed Original ResearchEpidemiology, Infection Prevention, Testing Data, and Clinical Outcomes of COVID-19 on Five Inpatient Psychiatric Units in a large Academic Medical Center
Li L, Roberts SC, Kulp W, Wing A, Barnes T, Colandrea N, Klink B, Fortunati F, Martinello R. Epidemiology, Infection Prevention, Testing Data, and Clinical Outcomes of COVID-19 on Five Inpatient Psychiatric Units in a large Academic Medical Center. Psychiatry Research 2021, 298: 113776. PMID: 33571800, PMCID: PMC7987366, DOI: 10.1016/j.psychres.2021.113776.Peer-Reviewed Original ResearchConceptsInpatient psychiatric unitLarge academic medical centerAcademic medical centerPsychiatric unitMedical CenterCOVID-19Retrospective cohort analysisEmergency room visitsInpatient psychiatric facilityLow patientsClinical outcomesRoom visitsHospitalized individualsInfection preventionStudy populationCohort analysisPrevention strategiesAdmission statusTriage protocolDiverse patientsInfection rateMental illnessPsychiatric facilitiesDemographic dataPatientsMass severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel
Roberts SC, Peaper DR, Thorne CD, Sussman LS, Murray TS, Choi SJ, Pettker CM, Russi MB, Martinello RA. Mass severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel. Infection Control And Hospital Epidemiology 2021, 42: 1-2. PMID: 33487206, PMCID: PMC7853752, DOI: 10.1017/ice.2021.9.Peer-Reviewed Original Research
2020
A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways
Lorenzo-Redondo R, Nam HH, Roberts SC, Simons LM, Jennings LJ, Qi C, Achenbach CJ, Hauser AR, Ison MG, Hultquist JF, Ozer EA. A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways. EBioMedicine 2020, 62: 103112. PMID: 33186810, PMCID: PMC7655495, DOI: 10.1016/j.ebiom.2020.103112.Peer-Reviewed Original ResearchConceptsPatient's upper airwayViral loadSARS-CoV-2Upper airwayHighest average viral loadSARS-CoV-2 infectionTranslational Research AwardTime of diagnosisAverage viral loadCOVID-19 patientsLow viral loadComprehensive cancer centerCoronavirus disease 2019SARS-CoV-2 isolatesSARS-CoV-2 virusClade 1 virusesClade 2 virusesRelative viral loadVirologic featuresClinical characteristicsClinical parametersCancer CenterDistinct viral cladesClinical significanceTranslational Science InstituteImpact of Screening and Treatment of Ureaplasma species on Hyperammonemia Syndrome in Lung Transplant Recipients: A Single Center Experience
Roberts SC, Bharat A, Kurihara C, Tomic R, Ison MG. Impact of Screening and Treatment of Ureaplasma species on Hyperammonemia Syndrome in Lung Transplant Recipients: A Single Center Experience. Clinical Infectious Diseases 2020, 73: e2531-e2537. PMID: 33068392, PMCID: PMC8563172, DOI: 10.1093/cid/ciaa1570.Peer-Reviewed Original ResearchConceptsLung transplant recipientsLung transplantUreaplasma sppHyperammonemia syndromePolymerase chain reactionTransplant recipientsUreaplasma speciesSingle-center experienceBronchoalveolar lavage cultureRecipients of organsNegative screening testImpact of screeningFuture confirmatory studiesEmpiric therapyNew onsetLung donorsCenter experienceDonor testingUrine cultureLavage cultureMental statusAntimicrobial therapyTransplantPatientsScreening testGlobal increases in antibiotic consumption: a concerning trend for WHO targets
Roberts SC, Zembower TR. Global increases in antibiotic consumption: a concerning trend for WHO targets. The Lancet Infectious Diseases 2020, 21: 10-11. PMID: 32717207, DOI: 10.1016/s1473-3099(20)30456-4.Peer-Reviewed Original ResearchResidual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages
Akbarpour M, Lecuona E, Chiu S, Wu Q, Querrey M, Fernandez R, Nunez-Santana F, Sun H, Ravi S, Kurihara C, Walter JM, Joshi N, Ren Z, Roberts SC, Hauser A, Kreisel D, Li W, Chandel N, Misharin AV, Mohanakumar T, Budinger GRS, Bharat A. Residual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages. Journal Of Clinical Investigation 2020, 130: 4456-4469. PMID: 32692317, PMCID: PMC7410086, DOI: 10.1172/jci135838.Peer-Reviewed Original ResearchConceptsTissue-resident alveolar macrophagesPrimary graft dysfunctionHuman donor lungsNeutrophil recruitmentGraft dysfunctionDonor lungsBacterial pneumoniaAlveolar macrophagesBone marrow chimeric miceDonor lung injuryActivation of TLR4Blockade of TLR4MyD88-dependent mannerResidual endotoxinCoreceptor CD14Lung transplantationLung injuryNeutrophil infiltrationFatal syndromeSuccessful treatmentMouse modelChimeric miceBacterial endotoxinTLR4Endotoxin
2019
Successful treatment of a Candida auris intra-articular infection
Roberts SC, Zembower TR, Bolon MK, Kadakia AR, Gilley JH, Ko JH, Clark J, Ward-Fore S, Taiwo BO. Successful treatment of a Candida auris intra-articular infection. Emerging Microbes & Infections 2019, 8: 866-868. PMID: 31179850, PMCID: PMC6566482, DOI: 10.1080/22221751.2019.1625287.Peer-Reviewed Original Research