2020
584. Ventricular assist device infections with Pseudomonas aeruginosa
Roberts S, Nam H, Kumar R, Zembower T, Qi C, Malczynski M, Rich J, Pawale A, Harap R, Stosor V. 584. Ventricular assist device infections with Pseudomonas aeruginosa. Open Forum Infectious Diseases 2020, 7: s356-s356. PMCID: PMC7776381, DOI: 10.1093/ofid/ofaa439.778.Peer-Reviewed Original ResearchDriveline exit siteVAD-specific infectionsVAD infectionsPA infectionVentricular assist device infectionVentricular assist device recipientsPseudomonas aeruginosaSuccessful heart transplantationInfection prevention strategiesNorthwestern Memorial HospitalMultiple antibiotic classesWarrants further studyAntibiotic coursesFQ monotherapyISHLT guidelinesProlonged antibioticsHeart transplantationSurgical debridementVAD implantationCerebrovascular accidentInitial diagnosisMedian timeDevice implantationDevice recipientsAntibiotic treatment520. Longitudinal Analysis of SARS-CoV-2 Viruses in Hospitalized Adults
Simons L, Lorenzo-Redondo R, Nam H, Roberts S, Ison M, Achenbach C, Hauser A, Ozer E, Hultquist J. 520. Longitudinal Analysis of SARS-CoV-2 Viruses in Hospitalized Adults. Open Forum Infectious Diseases 2020, 7: s325-s326. PMCID: PMC7776408, DOI: 10.1093/ofid/ofaa439.714.Peer-Reviewed Original ResearchSARS-CoV-2 viral loadViral loadSARS-CoV-2Hospitalized adultsPositive SARS-CoV-2 testSARS-CoV-2 testWhole viral genome sequencingNasopharyngeal viral loadResults 60 patientsNorthwestern Memorial HospitalCoronavirus disease 2019Viral load dataSARS-CoV-2 virusImmune selective pressureViral genome sequencingQuantitative reverse transcriptase PCRReverse transcriptase-PCRNasopharyngeal specimensNasopharyngeal swabsMemorial HospitalClinical dataIndividual patientsClinical consequencesDisease 2019Immune pressure864. Whole Genome Sequencing is Unable to Track Candida auris Transmission
Roberts S, Ozer E, Zembower T, Qi C. 864. Whole Genome Sequencing is Unable to Track Candida auris Transmission. Open Forum Infectious Diseases 2020, 7: s470-s471. PMCID: PMC7776755, DOI: 10.1093/ofid/ofaa439.1053.Peer-Reviewed Original ResearchNorthwestern Memorial HospitalWhole-genome sequencingC. aurisSingle nucleotide variantsDifferent body sitesMethods Whole-genome sequencingMemorial HospitalResults TwentyPatient isolatesSame patientTransmission clustersPatientsBody sitesPairwise SNP differencesOutbreak investigationHealthcare settingsCandida aurisHospital systemReference labIdentical isolatesAurisFluconazole sensitivityACLEnvironmental specimensCDC516. SARS-CoV-2 Exhibits Clade-specific Differences in Nasopharyngeal Viral Loads
Nam H, Lorenzo-Redondo R, Roberts S, Simons L, Achenbach C, Hauser A, Ison M, Hultquist J, Ozer E. 516. SARS-CoV-2 Exhibits Clade-specific Differences in Nasopharyngeal Viral Loads. Open Forum Infectious Diseases 2020, 7: s324-s324. PMCID: PMC7776718, DOI: 10.1093/ofid/ofaa439.710.Peer-Reviewed Original ResearchNasopharyngeal viral loadViral loadClinical significancePositive SARS-CoV-2 RTSARS-CoV-2 RTCoronavirus disease 2019Further longitudinal studiesNorthwestern Memorial HospitalSARS-CoV-2 isolatesCT valuesSARS-CoV-2SARS-CoV-2 genotypesClade 1 virusesViral cladesClade 2 virusesSymptom onsetClinical parametersNasopharyngeal swabsUpper airwayMemorial HospitalDistinct viral cladesClinical dataDisease 20191164. Epidemiology of Cryptococcal Infections in Non-HIV Patients: A 20-year Single Center Experience
Kumar R, Nam H, Roberts S, Penugonda S, Angarone M, Stosor V. 1164. Epidemiology of Cryptococcal Infections in Non-HIV Patients: A 20-year Single Center Experience. Open Forum Infectious Diseases 2020, 7: s608-s608. PMCID: PMC7776216, DOI: 10.1093/ofid/ofaa439.1350.Peer-Reviewed Original ResearchCryptococcal antigenRisk factorsCerebrospinal fluidSingle-center retrospective cohort studyCenter retrospective cohort studySolid organ transplant recipientsCommon predisposing conditionsNon-HIV patientsPositive cryptococcal antigenPositive culture dataRetrospective cohort studyChronic kidney diseaseOrgan transplant recipientsSingle-center experienceSolid organ transplantsTime of diagnosisUse of immunosuppressionNorthwestern Memorial HospitalCentral nervous systemSite of infectionHospital mortalityCryptococcal infectionTransplant recipientsCohort studyPredisposing conditionInfection with Ureaplasma spp in Lung Transplant Recipients is Donor-Derived
Roberts S, Bharat A, Kurihara C, Ison M. Infection with Ureaplasma spp in Lung Transplant Recipients is Donor-Derived. The Journal Of Heart And Lung Transplantation 2020, 39: s47. DOI: 10.1016/j.healun.2020.01.1220.Peer-Reviewed Original ResearchLung transplant recipientsUreaplasma sppHyperammonemia syndromeTransplant recipientsPositive donorsBronchoalveolar lavageMethods Consecutive patientsNorthwestern Memorial HospitalTime of implantationMicrobial confirmationConsecutive patientsDonor testingConclusions InfectionMemorial HospitalRisk factorsAntimicrobial therapyLTxRsResults SixtyMurine modelNegative testingPatientsActive malesPurpose Recent studiesInfectionHuman subjectsRisk Factors for Fungal Infection in a Ventricular Assist Device Cohort
Roberts S, Rich J, Pham D, Pawale A, Harap R, Wu T, Stosor V. Risk Factors for Fungal Infection in a Ventricular Assist Device Cohort. The Journal Of Heart And Lung Transplantation 2020, 39: s488. DOI: 10.1016/j.healun.2020.01.059.Peer-Reviewed Original ResearchRisk factorsFungal infectionsBacterial infectionsVAD implantationPolymicrobial infectionsVAD devicesVentricular assist device infectionMulti-drug resistant organismsConclusion Risk factorsVAD-related infectionsRetrospective cohort studyIndependent risk factorBinary logistic regression analysisSignificant risk factorsNorthwestern Memorial HospitalLogistic regression analysisHigh mortality rateSPSS Statistics version 25.0Device cohortMDRO infectionVAD infectionsVAD-specificUnderlying diagnosisCohort studyIschemic cardiomyopathy
2019
1180. Colonization with Multidrug-Resistant Organisms Is Associated with Subsequent Infection in the Ventricular Assist Device Population
Roberts S, Rich J, Pham D, Harap R, Stosor V. 1180. Colonization with Multidrug-Resistant Organisms Is Associated with Subsequent Infection in the Ventricular Assist Device Population. Open Forum Infectious Diseases 2019, 6: s423-s423. PMCID: PMC6809241, DOI: 10.1093/ofid/ofz360.1043.Peer-Reviewed Original ResearchVAD-related infectionsVentricular assist device populationMultidrug-resistant organismsVentricular assist deviceSubsequent infectionExact testAssist deviceMultidrug-resistant organism colonizationTwo-sided Fisher's exact testPeri-operative prophylaxisContinuous-flow ventricular assist devicesRetrospective cohort studyMethicillin-resistant Staphylococcus aureusExtended-spectrum β-lactamaseNorthwestern Memorial HospitalFisher's exact testLongitudinal retrospective cohortVancomycin-resistant Enterococcus faecalisSPSS Statistics version 25.0MDRO colonizationVAD populationVAD-specificCohort studyRetrospective cohortESBL organisms1771. Donor-derived Ureaplasma Infection Increases Mortality in Lung Transplant Recipients
Roberts S, Bharat A, Kurihara C, Bhorade S, Ison M. 1771. Donor-derived Ureaplasma Infection Increases Mortality in Lung Transplant Recipients. Open Forum Infectious Diseases 2019, 6: s653-s653. PMCID: PMC6809047, DOI: 10.1093/ofid/ofz360.1634.Peer-Reviewed Original ResearchDonor-derived infectionTime of LTxLung transplant recipientsHyperammonemia syndromeUreaplasma sppTransplant recipientsDonor screeningPCR testingPre-transplant screeningRetrospective cohort studyRenal replacement therapyBronchoalveolar lavage cultureNegative screening testNorthwestern Memorial HospitalSPSS Statistics version 25.0Donor transmissionEmpiric therapyCohort studyRetrospective cohortDonor testingUrine cultureLavage cultureReplacement therapyMemorial HospitalMental status