2022
Hyperammonemia syndrome in immunosuppressed individuals
Roberts SC, Malik W, Ison MG. Hyperammonemia syndrome in immunosuppressed individuals. Current Opinion In Infectious Diseases 2022, 35: 262-268. PMID: 35665721, PMCID: PMC9179651, DOI: 10.1097/qco.0000000000000828.Peer-Reviewed Original ResearchConceptsLung transplant recipientsHyperammonemia syndromeUreaplasma sppTransplant recipientsImmunosuppressed individualsSolid organ transplant populationLung transplant donorsOrgan transplant populationPeri-transplant periodAppropriate antimicrobial therapyUrease-producing organismsHigh mortality rateTransplant populationTransplant donorsClinical manifestationsFatal conditionAntimicrobial therapySurveillance studyMortality rateSystemic infectionSyndromeDonor colonizationAntibiotic resistanceRapid diagnosticsRecipients
2020
Impact of Screening and Treatment of Ureaplasma species on Hyperammonemia Syndrome in Lung Transplant Recipients: A Single Center Experience
Roberts SC, Bharat A, Kurihara C, Tomic R, Ison MG. Impact of Screening and Treatment of Ureaplasma species on Hyperammonemia Syndrome in Lung Transplant Recipients: A Single Center Experience. Clinical Infectious Diseases 2020, 73: e2531-e2537. PMID: 33068392, PMCID: PMC8563172, DOI: 10.1093/cid/ciaa1570.Peer-Reviewed Original ResearchConceptsLung transplant recipientsLung transplantUreaplasma sppHyperammonemia syndromePolymerase chain reactionTransplant recipientsUreaplasma speciesSingle-center experienceBronchoalveolar lavage cultureRecipients of organsNegative screening testImpact of screeningFuture confirmatory studiesEmpiric therapyNew onsetLung donorsCenter experienceDonor testingUrine cultureLavage cultureMental statusAntimicrobial therapyTransplantPatientsScreening testInfection with Ureaplasma spp in Lung Transplant Recipients is Donor-Derived
Roberts S, Bharat A, Kurihara C, Ison M. Infection with Ureaplasma spp in Lung Transplant Recipients is Donor-Derived. The Journal Of Heart And Lung Transplantation 2020, 39: s47. DOI: 10.1016/j.healun.2020.01.1220.Peer-Reviewed Original ResearchLung transplant recipientsUreaplasma sppHyperammonemia syndromeTransplant recipientsPositive donorsBronchoalveolar lavageMethods Consecutive patientsNorthwestern Memorial HospitalTime of implantationMicrobial confirmationConsecutive patientsDonor testingConclusions InfectionMemorial HospitalRisk factorsAntimicrobial therapyLTxRsResults SixtyMurine modelNegative testingPatientsActive malesPurpose Recent studiesInfectionHuman subjects
2019
1771. Donor-derived Ureaplasma Infection Increases Mortality in Lung Transplant Recipients
Roberts S, Bharat A, Kurihara C, Bhorade S, Ison M. 1771. Donor-derived Ureaplasma Infection Increases Mortality in Lung Transplant Recipients. Open Forum Infectious Diseases 2019, 6: s653-s653. PMCID: PMC6809047, DOI: 10.1093/ofid/ofz360.1634.Peer-Reviewed Original ResearchDonor-derived infectionTime of LTxLung transplant recipientsHyperammonemia syndromeUreaplasma sppTransplant recipientsDonor screeningPCR testingPre-transplant screeningRetrospective cohort studyRenal replacement therapyBronchoalveolar lavage cultureNegative screening testNorthwestern Memorial HospitalSPSS Statistics version 25.0Donor transmissionEmpiric therapyCohort studyRetrospective cohortDonor testingUrine cultureLavage cultureReplacement therapyMemorial HospitalMental status