Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial
Weiss M, Macklin E, McIlduff C, Vucic S, Wainger B, Kiernan M, Goutman S, Goyal N, Rutkove S, Ladha S, Chen I, Harms M, Brannagan T, Lacomis D, Zivkovic S, Ma M, Wang L, Simmons Z, Rivner M, Shefner J, Cudkowicz M, Atassi N, Group F. Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial. Muscle & Nerve 2020, 63: 371-383. PMID: 33340120, PMCID: PMC8513796, DOI: 10.1002/mus.27146.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmyotrophic Lateral SclerosisAxonsCortical ExcitabilityDouble-Blind MethodElectrodiagnosisElectromyographyEvoked Potentials, MotorFemaleHumansMaleMedian NerveMexiletineMiddle AgedNeural ConductionPreliminary DataTranscranial Magnetic StimulationVoltage-Gated Sodium Channel BlockersConceptsEffects of mexiletineResting motor thresholdSporadic amyotrophic lateral sclerosisRandomized controlled trialsAxonal hyperexcitabilityAmyotrophic lateral sclerosisRandomized to placeboAxonal excitability studiesCompared to placeboPhase II randomized controlled trialSecondary outcome measuresTranscranial magnetic stimulationPrimary endpointLateral sclerosisAxonal excitabilityHalf-timeTreated subjectsMexiletineReduction of motorControlled trialsHyperexcitabilityALS subjectsAlternative causesMagnetic stimulationOutcome measures