2006
Resistance to Oxidative Stress Is Associated with Metastasis in Mucocutaneous Leishmaniasis
Acestor N, Masina S, Ives A, Walker J, Saravia NG, Fasel N. Resistance to Oxidative Stress Is Associated with Metastasis in Mucocutaneous Leishmaniasis. The Journal Of Infectious Diseases 2006, 194: 1160-1167. PMID: 16991092, DOI: 10.1086/507646.Peer-Reviewed Original ResearchConceptsMucocutaneous leishmaniasisMetastatic phenotypeMetastatic diseaseCutaneous lesionsMicrobicidal responsesMetastatic disseminationGolden hamstersNasopharyngeal tissuesCytoplasmic peroxiredoxinOxidative stressLeishmania promastigotesNonmetastatic clonesL. panamensisLeishmaniasisHost cellsParasitesPhenotypePatientsMetastasisHeat shockPathogenesisLesionsPeroxidase activityDiseaseDissemination
2002
Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp
Travi BL, Osorio Y, Melby PC, Chandrasekar B, Arteaga L, Saravia NG. Gender Is a Major Determinant of the Clinical Evolution and Immune Response in Hamsters Infected with Leishmania spp. Infection And Immunity 2002, 70: 2288-2296. PMID: 11953362, PMCID: PMC127932, DOI: 10.1128/iai.70.5.2288-2296.2002.Peer-Reviewed Original ResearchConceptsFemale animalsGender-related differencesMale animalsImmune responseInterleukin-4Lesion sizeDistant cutaneous sitesPermissive immune responsePrepubertal male animalsSevere cutaneous lesionsSex hormone statusLeishmania sppTGF-beta mRNASeverity of diseaseAdult male animalsGreater lesion sizeGrowth factor betaGreater parasite burdenIntralesional expressionCutaneous sitesIL-10Lymph nodesChronic lesionsClinical evolutionCutaneous infections
1997
Carbohydrate and LPG expression in Leishmania viannia subgenus.
Muskus C, Segura I, Oddone R, Turco S, Leiby D, Toro L, Robledo S, Saravia N. Carbohydrate and LPG expression in Leishmania viannia subgenus. Journal Of Parasitology 1997, 83: 671-8. PMID: 9267410, DOI: 10.2307/3284245.Peer-Reviewed Original ResearchConceptsGrowth phaseLogarithmic phase promastigotesRepeat unitsViannia subgenusLPG repeat unitsSpecies referenceL. donovani lipophosphoglycanLPG expressionMolecular determinantsSubgeneraCell surfaceGlycosylated moleculesStationary phase promastigotesL. donovaniDistinct populationsBiochemical analysisExpression of carbohydratesSpeciesExpressionL. panamensisL. guyanensisSuch moleculesL. braziliensisLeishmania promastigotesFlow cytometry
1996
The inflammatory response promotes cutaneous metastasis in hamsters infected with Leishmania (Viannia) panamensis.
Travi B, Osorio Y, Saravia N. The inflammatory response promotes cutaneous metastasis in hamsters infected with Leishmania (Viannia) panamensis. Journal Of Parasitology 1996, 82: 454-7. PMID: 8636852, DOI: 10.2307/3284085.Peer-Reviewed Original ResearchConceptsInflammatory responseMetastatic lesionsControl animalsL. panamensisLeishmania panamensis infectionType hypersensitivity responseFrequency of metastasisNonspecific inflammatory responseDevelopment of lesionsExperimental groupElicitation of inflammationPanamensis infectionSkin metastasesCutaneous metastasesHind pawsSurgical excisionHypersensitivity responseSite of inductionIntradermal applicationSecondary diseaseHamster modelInflammatory stimuliLeishmania panamensisMetastasisLesions
1995
Genotypic polymorphisms in experimental metastatic dermal leishmaniasis
Pacheco R, Martinez J, Valderrama L, Momen H, Saravia N. Genotypic polymorphisms in experimental metastatic dermal leishmaniasis. Molecular And Biochemical Parasitology 1995, 69: 197-209. PMID: 7770084, DOI: 10.1016/0166-6851(94)00212-6.Peer-Reviewed Original Research
1991
Metastatic capability of Leishmania (Viannia) panamensis and Leishmania (Viannia) guyanensis in golden hamsters.
Martinez J, Travi B, Valencia A, Saravia N. Metastatic capability of Leishmania (Viannia) panamensis and Leishmania (Viannia) guyanensis in golden hamsters. Journal Of Parasitology 1991, 77: 762-8. PMID: 1919926, DOI: 10.2307/3282713.Peer-Reviewed Original ResearchConceptsCutaneous metastatic lesionsMetastatic lesionsFrequency of isolationLymph nodesL. panamensisL. guyanensisLeishmania panamensisLeishmania guyanensisGolden hamstersDistant lymph nodesCutaneous metastasesPrimary lesionLymphatic disseminationExperimental infectionLesionsMetastatic capabilityHuman casesTissue samplesHamstersParasite culturesSandfly vectorNineteen strainsInoculation siteGuyanensisInoculum dose
1988
Behavior of Leishmania braziliensis s.l. in golden hamsters: evolution of the infection under different experimental conditions.
Travi B, Rey-Ladino J, Saravia N. Behavior of Leishmania braziliensis s.l. in golden hamsters: evolution of the infection under different experimental conditions. Journal Of Parasitology 1988, 74: 1059-62. PMID: 3193329, DOI: 10.2307/3282237.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCricetinaeHydrocortisoneLeishmaniaLeishmania braziliensisLeishmaniasisLymph NodesMesocricetus