Regulatory T Cells in the Pathogenesis and Healing of Chronic Human Dermal Leishmaniasis Caused by Leishmania (Viannia) Species
Rodriguez-Pinto D, Navas A, Blanco VM, Ramírez L, Garcerant D, Cruz A, Craft N, Saravia NG. Regulatory T Cells in the Pathogenesis and Healing of Chronic Human Dermal Leishmaniasis Caused by Leishmania (Viannia) Species. PLOS Neglected Tropical Diseases 2012, 6: e1627. PMID: 22545172, PMCID: PMC3335885, DOI: 10.1371/journal.pntd.0001627.Peer-Reviewed Original ResearchMeSH KeywordsAsymptomatic DiseasesCD4 AntigensChronic DiseaseFemaleFlow CytometryForkhead Transcription FactorsGene Expression ProfilingGlucocorticoid-Induced TNFR-Related ProteinHumansImmunophenotypingInterferon-gammaInterleukin-2 Receptor alpha SubunitInterleukin-7 Receptor alpha SubunitLeishmaniaLeishmaniasis, CutaneousMaleSkinT-Lymphocytes, RegulatoryConceptsRegulatory T cellsIFN-γ secretionDermal leishmaniasisPeripheral bloodT cellsSuppressive capacityCD4 T-cell frequenciesImpaired Treg functionParticipation of TregsT cell frequenciesExpression of Foxp3CD4 T cellsEnd of treatmentHealing of lesionsCdLS patientsSkin test sitesSite biopsiesTreg subsetsImmunotherapeutic strategiesTreg functionEffector cellsCutaneous lesionsFoxp3 expressionCutaneous responseInflammatory response