Changes in Expression of Signal Transduction Proteins in T Lymphocytes of Patients with Leprosy
Zea A, Ochoa M, Ghosh P, Longo D, Alvord W, Valderrama L, Falabella R, Harvey L, Saravia N, Moreno L, Ochoa A. Changes in Expression of Signal Transduction Proteins in T Lymphocytes of Patients with Leprosy. Infection And Immunity 1998, 66: 499-504. PMID: 9453602, PMCID: PMC107934, DOI: 10.1128/iai.66.2.499-504.1998.Peer-Reviewed Original ResearchConceptsT cell dysfunctionDNA-binding patternsSignal transduction proteinsSignal transduction moleculesLeprosy patientsCore promoter regionLL patientsTransduction proteinsT-cell receptor zeta chain expressionTransduction moleculesPromoter regionTyrosine kinaseTuberculoid leprosy patientsZeta chain expressionLepromatous leprosy patientsT cell functionSignal transduction alterationsNF-kappaB p65Electrophoretic mobilityImmunologic evaluationT cellsT lymphocytesMycobacterial diseasePatientsAdvanced stage