2013
Detection of Leishmania RNA Virus in Leishmania Parasites
Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N. Detection of Leishmania RNA Virus in Leishmania Parasites. PLOS Neglected Tropical Diseases 2013, 7: e2006. PMID: 23326619, PMCID: PMC3542153, DOI: 10.1371/journal.pntd.0002006.Peer-Reviewed Original ResearchConceptsLeishmania RNA virusCutaneous leishmaniasisSkin lesionsPresence of LRVHyper-inflammatory immune responsePrimary skin lesionsUlcerated skin lesionsOverall exacerbationsSignificant morbidityInfected miceLesion biopsyRNA virusesSecondary lesionsImmune responseHigh riskNew World Leishmania speciesAggressive phenotypeLeishmania strainsLeishmania parasitesPatient samplesViral detectionMonoclonal antibodiesNasopharyngeal tissuesParasite strainsMetastatic phenotype
2003
Mapping the proteome of Leishmania Viannia parasites using two-dimensional polyacrylamide gel electrophoresis and associated technologies.
Góngora R, Acestor N, Quadroni M, Fasel N, Saravia NG, Walker J. Mapping the proteome of Leishmania Viannia parasites using two-dimensional polyacrylamide gel electrophoresis and associated technologies. Biomédica 2003, 23: 153-60. PMID: 12872554, DOI: 10.7705/biomedica.v23i2.1207.Peer-Reviewed Original ResearchConceptsProteome mapProteome analysisHeat shock protein familyRibosomal protein S12Comparative proteome analysisPeptide mass spectrometryTwo-dimensional polyacrylamide gel electrophoresisParaflagellar rod proteins 1Shock protein familyProtein expression profilesSpecies/strainsTwo-dimensional electrophoresisProtein expression studiesProtein S12Protein familyBioinformatics approachDistinct proteinsProtein spotsProtein mapsProtein 11Expression studiesExpression profilesUnknown functionDistinct parasite clonesPolyacrylamide gel electrophoresis