2010
Murine model of chronic L. (Viannia) panamensis infection: Role of IL‐13 in disease
Castilho TM, Goldsmith‐Pestana K, Lozano C, Valderrama L, Saravia NG, McMahon‐Pratt D. Murine model of chronic L. (Viannia) panamensis infection: Role of IL‐13 in disease. European Journal Of Immunology 2010, 40: 2816-2829. PMID: 20827674, PMCID: PMC3289133, DOI: 10.1002/eji.201040384.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsChronic DiseaseDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleHumansInterferon-gammaInterleukin-13LeishmaniaLeishmaniasis, CutaneousMaleMiceMice, Inbred BALB CMice, KnockoutMiddle AgedReceptors, Interleukin-4Th1 CellsTh2 CellsTumor Necrosis Factor-alphaYoung AdultConceptsL. panamensis infectionsIL-13Panamensis infectionChronic diseasesImmunodeficient miceMurine modelMixed Th1/Th2 responseBALB/c mouse modelTh1/Th2 responsePrevalent etiologic agentHuman cutaneous leishmaniasisPresence of TNFPrevention of leishmaniasisIL-17Immunological mechanismsTh2 responsesIL-10Recurrent lesionsChronic infectionEvident lesionsMice resemblesT cellsImmune responsePersistent infectionLeishmania organisms
1990
Recurrent lesions in human Leishmania braziliensis infection—reactivation or reinfection?
Saravia N, Segura I, Labrada L, Weigle K, Giannini S, Pacheco R, Goncalves A. Recurrent lesions in human Leishmania braziliensis infection—reactivation or reinfection? The Lancet 1990, 336: 398-402. PMID: 1974943, DOI: 10.1016/0140-6736(90)91945-7.Peer-Reviewed Original ResearchConceptsRecurrent lesionsInitial lesionLonger disease-free intervalDisease-free intervalAmerican tegumentary leishmaniasisRecurrent diseaseEndogenous reactivationExogenous reinfectionVaccination strategiesClinical dataPatientsTegumentary leishmaniasisLesionsTreatment evaluationRecurrent strainsLeishmania braziliensisIdentical strainsLatter groupReinfectionRestriction endonuclease analysisEndonuclease analysisStrain pairsMolecular karyotypingKaryotype profilePolymorphism