2013
Detection of Leishmania RNA Virus in Leishmania Parasites
Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N. Detection of Leishmania RNA Virus in Leishmania Parasites. PLOS Neglected Tropical Diseases 2013, 7: e2006. PMID: 23326619, PMCID: PMC3542153, DOI: 10.1371/journal.pntd.0002006.Peer-Reviewed Original ResearchConceptsLeishmania RNA virusCutaneous leishmaniasisSkin lesionsPresence of LRVHyper-inflammatory immune responsePrimary skin lesionsUlcerated skin lesionsOverall exacerbationsSignificant morbidityInfected miceLesion biopsyRNA virusesSecondary lesionsImmune responseHigh riskNew World Leishmania speciesAggressive phenotypeLeishmania strainsLeishmania parasitesPatient samplesViral detectionMonoclonal antibodiesNasopharyngeal tissuesParasite strainsMetastatic phenotype
1996
Leishmania RNA viruses in Leishmania of the Viannia subgenus.
Salinas G, Zamora M, Stuart K, Saravia N. Leishmania RNA viruses in Leishmania of the Viannia subgenus. American Journal Of Tropical Medicine And Hygiene 1996, 54: 425-9. PMID: 8615459, DOI: 10.4269/ajtmh.1996.54.425.Peer-Reviewed Original ResearchConceptsL. braziliensisL. braziliensis strainWorld Health Organization referenceViannia subgenusLeishmania RNA virusCapsid protein fragmentMucosal lesionsStrains of LeishmaniaEpidemiologic markersMetastatic traitsVirus presentKaryotype analysisMaterial reactiveColombian strainL. guyanensisVirusBraziliensisLeishmaniaLRV1Polyclonal antibodiesRNA virusesRecombinant fragmentsTotal lysatesReference strainsBiological characterization