2013
Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival
Gómez MA, Navas A, Márquez R, Rojas LJ, Vargas DA, Blanco VM, Koren R, Zilberstein D, Saravia NG. Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival. Journal Of Antimicrobial Chemotherapy 2013, 69: 139-149. PMID: 23975742, PMCID: PMC3861331, DOI: 10.1093/jac/dkt334.Peer-Reviewed Original ResearchConceptsIntracellular parasite survivalParasite survivalIntracellular pathogensRNA gene knockdownDrug response genesGene expression profilingHost cell mechanismsHost cell determinantsSurvival of LeishmaniaFunctional validationExpression profilingGene knockdownGene expressionDrug transportersQuantitative RT-PCRPhagolysosomal membraneOutcome of treatmentCell-mediated regulationIntracellular parasite killingNovel mechanismPharmacokinetics/pharmacodynamicsPrimary macrophagesMetallothionein 2AHuman macrophagesTransporters
2009
Role of Toll-like receptors in the response of human macrophages to Leishmania panamensis infection (133.17)
Gallego C, Saravia N, Valderrama L, Golenbock D. Role of Toll-like receptors in the response of human macrophages to Leishmania panamensis infection (133.17). The Journal Of Immunology 2009, 182: 133.17-133.17. DOI: 10.4049/jimmunol.182.supp.133.17.Peer-Reviewed Original ResearchToll-like receptorsOutcome of infectionPanamensis infectionHuman macrophagesTLR ligandsL. panamensisExpression of TLR1L. panamensis infectionsLeishmania panamensis infectionActivation of TLR2Production of TNFαAmerican cutaneous leishmaniasisHuman primary macrophagesL. panamensis promastigotesPossible roleHealthy donorsCutaneous leishmaniasisTNFα productionInnate recognitionWild-type (WT) mouse macrophagesInfectionPrimary macrophagesTLR2MacrophagesPhagocytic cells