2018
Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure–response relationships
Kip AE, del Mar Castro M, Gomez MA, Cossio A, Schellens JHM, Beijnen JH, Saravia NG, Dorlo TPC. Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure–response relationships. Journal Of Antimicrobial Chemotherapy 2018, 73: 2104-2111. PMID: 29757380, PMCID: PMC6251527, DOI: 10.1093/jac/dky143.Peer-Reviewed Original ResearchConceptsExposure-response relationshipProbability of curePopulation PK modelMiltefosine concentrationsDosing simulationsPK targetPK modelNew World cutaneous leishmaniasisPlasma concentration-time curveCutaneous leishmaniasis patientsPopulation pharmacokinetic modelLarge cohort studyPopulation pharmacokinetic modellingConcentration-time curvePlasma concentration ratioDistribution rate constantMiltefosine exposureCohort studyLeishmaniasis patientsPatient populationEffect compartmentCutaneous leishmaniasisDay 1Three-compartment modelPharmacokinetic modelling
2000
Evaluation of Polymerase Chain Reaction, Adenosine Deaminase, and Interferon-γ in Pleural Fluid for the Differential Diagnosis of Pleural Tuberculosis
Villegas M, Labrada L, Saravia N. Evaluation of Polymerase Chain Reaction, Adenosine Deaminase, and Interferon-γ in Pleural Fluid for the Differential Diagnosis of Pleural Tuberculosis. CHEST Journal 2000, 118: 1355-1364. PMID: 11083686, DOI: 10.1378/chest.118.5.1355.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine DeaminaseAge FactorsBacteriological TechniquesBayes TheoremBiopsyBloodChi-Square DistributionDiagnosis, DifferentialDNA, BacterialFemaleFeverHumansInterferon-gammaMaleMiddle AgedMycobacterium tuberculosisPleural DiseasesPleural EffusionPleural NeoplasmsPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificitySputumTuberculosis, PleuralConceptsIFN-gamma levelsADA activity determinationPleural tuberculosisPolymerase chain reactionPleural effusionPleural fluidADA activityNonspecific clinical presentationPleural biopsy specimensTuberculous pleural effusionChain reactionAlternative diagnostic strategiesDifferent clinical settingsNegative predictive valueMeasurement of interferonAdenosine deaminase activityCombination of PCRMalignant etiologyUndetermined etiologyClinical presentationPaucibacillary natureClinical variablesPatient populationPleural biopsyDiagnostic challenge