2013
Detection of Leishmania RNA Virus in Leishmania Parasites
Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N. Detection of Leishmania RNA Virus in Leishmania Parasites. PLOS Neglected Tropical Diseases 2013, 7: e2006. PMID: 23326619, PMCID: PMC3542153, DOI: 10.1371/journal.pntd.0002006.Peer-Reviewed Original ResearchConceptsLeishmania RNA virusCutaneous leishmaniasisSkin lesionsPresence of LRVHyper-inflammatory immune responsePrimary skin lesionsUlcerated skin lesionsOverall exacerbationsSignificant morbidityInfected miceLesion biopsyRNA virusesSecondary lesionsImmune responseHigh riskNew World Leishmania speciesAggressive phenotypeLeishmania strainsLeishmania parasitesPatient samplesViral detectionMonoclonal antibodiesNasopharyngeal tissuesParasite strainsMetastatic phenotype
2006
Evidence for Leishmania (Viannia) Parasites in the Skin and Blood of Patients Before and After Treatment
Vergel C, Palacios R, Cadena H, Posso CJ, Valderrama L, Perez M, Walker J, Travi BL, Saravia NG. Evidence for Leishmania (Viannia) Parasites in the Skin and Blood of Patients Before and After Treatment. The Journal Of Infectious Diseases 2006, 194: 503-511. PMID: 16845635, DOI: 10.1086/505583.Peer-Reviewed Original ResearchConceptsPeripheral blood monocytesAmerican cutaneous leishmaniasisCutaneous leishmaniasisLeishmania parasitesUnaffected skinAnthroponotic transmissionAcquisition of infectionBlood of patientsSource of infectionSand fliesAdult patientsLesion scarTreatment failureAntimonial drugsPatientsNormal skinLeishmaniasisMonocytesZoonotic diseaseLesion bordersSkinTreatmentMolecular detection methodsPositive resultsInfection
1992
Haemoculture of Leishmania (Viannia) braziliensis from two cases of mucosal leishmaniasis: Re-examination of haematogenous dissemination
Martinez J, Alba, Arias L, Escobar M, Saravia N. Haemoculture of Leishmania (Viannia) braziliensis from two cases of mucosal leishmaniasis: Re-examination of haematogenous dissemination. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 1992, 86: 392-394. PMID: 1440813, DOI: 10.1016/0035-9203(92)90233-3.Peer-Reviewed Original ResearchConceptsMucosal leishmaniasisActive pulmonary tuberculosisMontenegro skin testPeripheral blood leucocytesIsolation of parasitesIndirect fluorescent antibodyCases of leishmaniasisCulture of parasitesHaematogenous disseminationMucosal involvementPulmonary tuberculosisCutaneous lesionsSkin testMucosal diseaseMetastatic spreadMonths durationBlood leucocytesRight legPatientsLeishmania parasitesLeishmania braziliensisL. braziliensisLeishmaniasisFluorescent antibodyLeucocytes