2023
Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study
del Mar Castro M, Rode J, Machado P, Llanos-Cuentas A, Hueb M, Cota G, Rojas I, Orobio Y, Sarmiento O, Rojas E, Quintero J, Pimentel M, Soto J, Suprien C, Alvarez F, Ramos A, dos Santos Arantes R, da Silva R, Arenas C, Vélez I, Lyra M, Saravia N, Arana B, Alexander N. Cutaneous leishmaniasis treatment and therapeutic outcomes in special populations: A collaborative retrospective study. PLOS Neglected Tropical Diseases 2023, 17: e0011029. PMID: 36689465, PMCID: PMC9894540, DOI: 10.1371/journal.pntd.0011029.Peer-Reviewed Original ResearchConceptsCollaborative retrospective studyRetrospective studyAdverse reactionsCutaneous leishmaniasisAge groupsMedian lesion diameterOverall cure rateOlder adult patientsMost adverse reactionsCutaneous leishmaniasis treatmentYears of ageMonotherapy regimenAdult patientsReferral centerLocal therapyPediatric populationClinical recordsCure rateCL patientsTherapeutic responseClinical trialsDisease presentationMedian numberMild intensityAntileishmanial treatment
1989
The Relationship of Leishmania braziliensis Subspecies and Immune Response to Disease Expression in New World Leishmaniasis
Saravia N, Valderrama L, Labrada M, Holguin A, Navas C, Palma G, Weigle K. The Relationship of Leishmania braziliensis Subspecies and Immune Response to Disease Expression in New World Leishmaniasis. The Journal Of Infectious Diseases 1989, 159: 725-735. PMID: 2647862, DOI: 10.1093/infdis/159.4.725.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntibodies, ProtozoanAntigens, ProtozoanDose-Response Relationship, ImmunologicFluorescent Antibody TechniqueHost-Parasite InteractionsHumansHypersensitivity, DelayedImmune SeraImmunity, CellularKineticsLeishmaniaLeishmania braziliensisLeishmaniasisLeishmaniasis, MucocutaneousLymphocyte ActivationRegression AnalysisConceptsCutaneous DTHLeishmania antigenBraziliensis infectionTegumentary leishmaniasisIFAT titersDisease formsVitro lymphocyte proliferative responseCutaneous DTH responseHuman tegumentary leishmaniasisL. braziliensis infectionLymphocyte proliferative responsesImmune response parametersHigher IFAT titersNew World leishmaniasisPanamensis infectionDTH responseMucocutaneous diseaseClinical presentationLesion durationCutaneous diseaseDisease presentationImmune mechanismsImmune responseProliferative responseTime of evolution