1997
In Situ Characterization of the Human Host Response to Leishmania panamensis
Palma G, Saravia N. In Situ Characterization of the Human Host Response to Leishmania panamensis. American Journal Of Dermatopathology 1997, 19: 585-590. PMID: 9415615, DOI: 10.1097/00000372-199712000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, ProtozoanAntigen-Antibody ReactionsAntigens, ProtozoanBiomarkersBiopsyCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEpidermisFluorescent Antibody Technique, IndirectGranulocytesGranulomaHumansImmunity, CellularImmunohistochemistryLeishmaniaLeishmaniasisLymphocyte ActivationMaleMiddle AgedNecrosisRegression AnalysisSkinConceptsHuman host responseHost responseLeishmania panamensisPresence of amastigotesT cell subpopulationsImmune response dataIndirect immunoperoxidase methodCD8 ratioDermal infiltrateMale patientsHistopathologic changesParticular cell populationPrognostic indicatorLeishmania infectionSkin biopsiesPlasma cellsT cellsDermal distributionCutaneous leishmaniasisProspective analysisB cellsB lymphocytesUpper dermisImmunoperoxidase methodDisease evolution
1993
Leishmania (Viannia) panamensis-specific IgE and IgA antibodies in relation to expression of human tegumentary leishmaniasis.
O'Neil C, Labrada M, Saravia N. Leishmania (Viannia) panamensis-specific IgE and IgA antibodies in relation to expression of human tegumentary leishmaniasis. American Journal Of Tropical Medicine And Hygiene 1993, 49: 181-8. PMID: 8357080, DOI: 10.4269/ajtmh.1993.49.181.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntibodies, ProtozoanAntibody SpecificityAntigens, ProtozoanChildChild, PreschoolCross ReactionsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin AImmunoglobulin EInfantLeishmania braziliensisLeishmaniasis, CutaneousLeishmaniasis, MucocutaneousMaleRadioallergosorbent TestRetrospective StudiesConceptsAmerican tegumentary leishmaniasisIgA antibodiesEnzyme-linked immunosorbent assayTegumentary leishmaniasisRadioallergosorbent testRAST valuesHuman tegumentary leishmaniasisDuration of diseaseIgA levelsMucocutaneous diseaseBiopsy specimenBiopsy specimensCutaneous diseaseSevere formPatientsHeterologous antigensDisease evolutionIgEImmunosorbent assayElevated levelsLeishmaniasisDiseaseInhibition testingAntibodiesSeparate groups