2000
Evaluation of Polymerase Chain Reaction, Adenosine Deaminase, and Interferon-γ in Pleural Fluid for the Differential Diagnosis of Pleural Tuberculosis
Villegas M, Labrada L, Saravia N. Evaluation of Polymerase Chain Reaction, Adenosine Deaminase, and Interferon-γ in Pleural Fluid for the Differential Diagnosis of Pleural Tuberculosis. CHEST Journal 2000, 118: 1355-1364. PMID: 11083686, DOI: 10.1378/chest.118.5.1355.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine DeaminaseAge FactorsBacteriological TechniquesBayes TheoremBiopsyBloodChi-Square DistributionDiagnosis, DifferentialDNA, BacterialFemaleFeverHumansInterferon-gammaMaleMiddle AgedMycobacterium tuberculosisPleural DiseasesPleural EffusionPleural NeoplasmsPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificitySputumTuberculosis, PleuralConceptsIFN-gamma levelsADA activity determinationPleural tuberculosisPolymerase chain reactionPleural effusionPleural fluidADA activityNonspecific clinical presentationPleural biopsy specimensTuberculous pleural effusionChain reactionAlternative diagnostic strategiesDifferent clinical settingsNegative predictive valueMeasurement of interferonAdenosine deaminase activityCombination of PCRMalignant etiologyUndetermined etiologyClinical presentationPaucibacillary natureClinical variablesPatient populationPleural biopsyDiagnostic challenge
1991
Correlation between histopathology, immune response, clinical presentation, and evolution in Leishmania braziliensis infection.
Gutierrez Y, Salinas G, Palma G, Valderrama L, Santrich C, Saravia N. Correlation between histopathology, immune response, clinical presentation, and evolution in Leishmania braziliensis infection. American Journal Of Tropical Medicine And Hygiene 1991, 45: 281-9. PMID: 1928562, DOI: 10.4269/ajtmh.1991.45.281.Peer-Reviewed Original ResearchConceptsPresence of amastigotesImmune responseClinical presentationLeishmania-specific immune responseAbsence of amastigotesPresence of epithelioidLymphocyte transformation responsesPresence of granulomasRole of antibodiesCellular immune responsesPresence of eosinophilsSerum antibody titersLeishmania braziliensis infectionPresence of LeishmaniaLeishmanial lesionsBraziliensis infectionCellular infiltrateType hypersensitivityClinical parametersActive lesionsAntibody titersEvolution of diseaseSoluble mediatorsTegumentary leishmaniasisEpitheloid cells
1990
Mucosal disease caused by Leishmania braziliensis guyanensis.
Santrich C, Segura I, Arias A, Saravia N. Mucosal disease caused by Leishmania braziliensis guyanensis. American Journal Of Tropical Medicine And Hygiene 1990, 42: 51-5. PMID: 2301705, DOI: 10.4269/ajtmh.1990.42.51.Peer-Reviewed Original Research
1989
The Relationship of Leishmania braziliensis Subspecies and Immune Response to Disease Expression in New World Leishmaniasis
Saravia N, Valderrama L, Labrada M, Holguin A, Navas C, Palma G, Weigle K. The Relationship of Leishmania braziliensis Subspecies and Immune Response to Disease Expression in New World Leishmaniasis. The Journal Of Infectious Diseases 1989, 159: 725-735. PMID: 2647862, DOI: 10.1093/infdis/159.4.725.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntibodies, ProtozoanAntigens, ProtozoanDose-Response Relationship, ImmunologicFluorescent Antibody TechniqueHost-Parasite InteractionsHumansHypersensitivity, DelayedImmune SeraImmunity, CellularKineticsLeishmaniaLeishmania braziliensisLeishmaniasisLeishmaniasis, MucocutaneousLymphocyte ActivationRegression AnalysisConceptsCutaneous DTHLeishmania antigenBraziliensis infectionTegumentary leishmaniasisIFAT titersDisease formsVitro lymphocyte proliferative responseCutaneous DTH responseHuman tegumentary leishmaniasisL. braziliensis infectionLymphocyte proliferative responsesImmune response parametersHigher IFAT titersNew World leishmaniasisPanamensis infectionDTH responseMucocutaneous diseaseClinical presentationLesion durationCutaneous diseaseDisease presentationImmune mechanismsImmune responseProliferative responseTime of evolution