2007
Treponema pallidum Elicits Innate and Adaptive Cellular Immune Responses in Skin and Blood during Secondary Syphilis: A Flow-Cytometric Analysis
Salazar JC, Cruz AR, Pope CD, Valderrama L, Trujillo R, Saravia NG, Radolf JD. Treponema pallidum Elicits Innate and Adaptive Cellular Immune Responses in Skin and Blood during Secondary Syphilis: A Flow-Cytometric Analysis. The Journal Of Infectious Diseases 2007, 195: 879-887. PMID: 17299719, PMCID: PMC2131710, DOI: 10.1086/511822.Peer-Reviewed Original ResearchConceptsCellular immune responsesPeripheral bloodT cellsSecondary syphilisBlister fluidImmune responseControl subjectsDC-specific intercellular adhesion molecule 3DC-SIGNSystemic cellular immune responsesAdaptive cellular immune responsesEpidermal suction blistersIntercellular adhesion molecule 3Plasmacytoid dendritic cellsDermal T cellsHealthy control subjectsHuman leukocyte antigenActivation marker CD69Adaptive immune responsesMonocytes/macrophagesFlow cytometric analysisDermal leukocytesLeukocyte immunophenotypesHIV coreceptorsDendritic cells
2006
Comparative immunohistological analysis of the Montenegro skin test reaction in asymptomatic infection and in acute and chronic cutaneous leishmaniasis
Guarín N, Palma G, Pirmez C, Valderrama L, Tovar R, Saravia NG. Comparative immunohistological analysis of the Montenegro skin test reaction in asymptomatic infection and in acute and chronic cutaneous leishmaniasis. Biomédica 2006, 26: 38-48. PMID: 17361840, DOI: 10.7705/biomedica.v26i1.1498.Peer-Reviewed Original ResearchConceptsSkin test reactionsMontenegro skin testSkin testChronic lesionsAcute lesionsAsymptomatic infectionT lymphocytesImmune responseB cellsComparative immunohistological analysisProportion of CD4Chronic cutaneous leishmaniasisType hypersensitivity reactionCellular immune responsesSkin test sitesTest reactionsLeishmaniasis lesionsCellular infiltrateHypersensitivity reactionsLeishmania infectionChronic diseasesInflammatory responseChronic patientsT cellsCutaneous leishmaniasis
1991
Correlation between histopathology, immune response, clinical presentation, and evolution in Leishmania braziliensis infection.
Gutierrez Y, Salinas G, Palma G, Valderrama L, Santrich C, Saravia N. Correlation between histopathology, immune response, clinical presentation, and evolution in Leishmania braziliensis infection. American Journal Of Tropical Medicine And Hygiene 1991, 45: 281-9. PMID: 1928562, DOI: 10.4269/ajtmh.1991.45.281.Peer-Reviewed Original ResearchConceptsPresence of amastigotesImmune responseClinical presentationLeishmania-specific immune responseAbsence of amastigotesPresence of epithelioidLymphocyte transformation responsesPresence of granulomasRole of antibodiesCellular immune responsesPresence of eosinophilsSerum antibody titersLeishmania braziliensis infectionPresence of LeishmaniaLeishmanial lesionsBraziliensis infectionCellular infiltrateType hypersensitivityClinical parametersActive lesionsAntibody titersEvolution of diseaseSoluble mediatorsTegumentary leishmaniasisEpitheloid cells