2019
Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy
LOGANADANE G, KANN BH, PARK HS, JOHNSON SB, MEHRA S, JUDSON BL, BHATIA A, BELKACEMI Y, YARBROUGH WG, BURTNESS B, HUSAIN ZA. Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy. Anticancer Research 2019, 39: 4885-4890. PMID: 31519591, DOI: 10.21873/anticanres.13674.Peer-Reviewed Original ResearchConceptsLocoregional recurrence-free survivalAdjuvant therapyNeck squamous cell carcinomaOutcomes of patientsRecurrence-free survivalSquamous cell carcinomaNeck cancer patientsHNSCC patientsClinical outcomesRecurrence rateCell carcinomaMean TTPCancer patientsPatientsTherapyResectionMonthsOutcomesHNSCCSurgeryCarcinomaHeadIncidenceProgression
2017
Outcomes and reliability of the flow coupler in postoperative monitoring of head and neck free flaps
Fujiwara RJT, Dibble JM, Larson SV, Pierce ML, Mehra S. Outcomes and reliability of the flow coupler in postoperative monitoring of head and neck free flaps. The Laryngoscope 2017, 128: 812-817. PMID: 28988465, DOI: 10.1002/lary.26944.Peer-Reviewed Original ResearchAdultAgedAged, 80 and overFalse Positive ReactionsFemaleFree Tissue FlapsGraft SurvivalHead and Neck NeoplasmsHumansLogistic ModelsMaleMiddle AgedMonitoring, PhysiologicMouth NeoplasmsPlastic Surgery ProceduresPostoperative ComplicationsPostoperative PeriodReproducibility of ResultsRetrospective StudiesRheologySensitivity and SpecificityVenous ThrombosisYoung AdultA Comparison of Prognostic Ability of Staging Systems for Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma
Husain ZA, Chen T, Corso CD, Wang Z, Park H, Judson B, Yarbrough W, Deshpande H, Mehra S, Kuo P, Decker RH, Burtness BA. A Comparison of Prognostic Ability of Staging Systems for Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma. JAMA Oncology 2017, 3: 358-365. PMID: 27737449, DOI: 10.1001/jamaoncol.2016.4581.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell cancerAJCC/UICC systemStaging systemStage IAStage IBHuman papillomavirusPrognostic abilityUICC systemAJCC/UICC staging systemStage IICurrent American Joint CommitteeOropharyngeal squamous cell carcinomaInternational Cancer Control (UICC) staging systemOropharyngeal cancer NetworkNational Cancer DatabasePrimary radiation therapyOverall survival rateAmerican Joint CommitteeCancer/UnionEdition staging systemKaplan-Meier methodSquamous cell cancerNovel staging systemSquamous cell carcinomaLog-rank test
2016
Proposing prognostic thresholds for lymph node yield in clinically lymph node‐negative and lymph node‐positive cancers of the oral cavity
Kuo P, Mehra S, Sosa JA, Roman SA, Husain ZA, Burtness BA, Tate JP, Yarbrough WG, Judson BL. Proposing prognostic thresholds for lymph node yield in clinically lymph node‐negative and lymph node‐positive cancers of the oral cavity. Cancer 2016, 122: 3624-3631. PMID: 27479645, DOI: 10.1002/cncr.30227.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseOral cavity cancerMortality hazard ratioLymph nodesHazard ratioNeck dissectionLymph node-negative cancersLymph node-positive cancersNode-positive cancersNode-positive cohortPositive lymph nodesTherapeutic neck dissectionEnd Results (SEER) databaseLymph node yieldHigh-volume centersExtensive neck dissectionMultiple cancer sitesNode-negative cancersOverall survivalHigher lymphPrognostic factorsTreatment guidelinesNode yieldResults databaseSurgical managementTreatment trends and survival effects of chemotherapy for hypopharyngeal cancer: Analysis of the National Cancer Data Base
Kuo P, Sosa JA, Burtness BA, Husain ZA, Mehra S, Roman SA, Yarbrough WG, Judson BL. Treatment trends and survival effects of chemotherapy for hypopharyngeal cancer: Analysis of the National Cancer Data Base. Cancer 2016, 122: 1853-1860. PMID: 27019213, DOI: 10.1002/cncr.29962.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCarcinoma, Squamous CellChemoradiotherapy, AdjuvantDatabases, FactualFemaleHead and Neck NeoplasmsHumansHypopharyngeal NeoplasmsKaplan-Meier EstimateMaleMiddle AgedProportional Hazards ModelsRadiotherapy, AdjuvantSquamous Cell Carcinoma of Head and NeckUnited StatesYoung AdultConceptsHypopharyngeal cancerDefinitive settingTreatment modalitiesSurvival rateNational Cancer Data BaseMultivariate Cox regression analysisKaplan-Meier survival curvesPrimary hypopharyngeal cancerUse of chemotherapyCox regression analysisDefinitive chemoradiotherapyAdjuvant chemoradiotherapyAdjuvant treatmentDefinitive radiotherapyAdult patientsOverall survivalClinical factorsDefinitive treatmentImproved survivalDistant metastasisSurvival outcomesChemoradiotherapyRadiotherapySurvival analysisSurvival curves
2015
National treatment patterns in patients presenting with Stage IVC head and neck cancer: analysis of the National Cancer Database
Schwam ZG, Burtness B, Yarbrough WG, Mehra S, Husain Z, Judson BL. National treatment patterns in patients presenting with Stage IVC head and neck cancer: analysis of the National Cancer Database. Cancer Medicine 2015, 4: 1828-1835. PMID: 26471244, PMCID: PMC5123708, DOI: 10.1002/cam4.546.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCombined Modality TherapyComorbidityDatabases, FactualFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm MetastasisNeoplasm StagingPopulation SurveillanceRetrospective StudiesRisk FactorsTreatment OutcomeUnited StatesYoung AdultConceptsNational Cancer DatabaseSystemic therapyPalliative therapyTreatment patternsNeck cancerCancer DatabaseClinical trialsMedicaid/uninsured statusCox proportional hazards analysisCommon treatment regimenNational treatment patternsCharlson comorbidity scorePrimary disease siteRetrospective cohort analysisProportional hazards analysisRisk of deathNeck cancer patientsMedicare/Comorbidity scoreMetastatic headOverall survivalSystemic treatmentTreatment regimenDistant metastasisKaplan-MeierHospital readmission and 30‐day mortality after surgery for oral cavity cancer: Analysis of 21,681 cases
Luryi AL, Chen MM, Mehra S, Roman SA, Sosa JA, Judson BL. Hospital readmission and 30‐day mortality after surgery for oral cavity cancer: Analysis of 21,681 cases. Head & Neck 2015, 38: e221-e226. PMID: 25537226, DOI: 10.1002/hed.23973.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell cancerSquamous cell cancerNational Cancer Data BaseHospital readmissionHigh-risk patientsUnplanned readmission rateComorbidity indexUnplanned readmissionNeck dissectionReadmission ratesOverall mortalityCell cancerStage T3Male sexRisk factorsRetrospective analysisAge 76Mortality rateReadmissionMortalityPatientsSurgeryT3T4Years
2014
Positive Surgical Margins in Early Stage Oral Cavity Cancer: An Analysis of 20,602 Cases
Luryi AL, Chen MM, Mehra S, Roman SA, Sosa JA, Judson BL. Positive Surgical Margins in Early Stage Oral Cavity Cancer: An Analysis of 20,602 Cases. Otolaryngology 2014, 151: 984-990. PMID: 25257901, DOI: 10.1177/0194599814551718.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnalysis of VarianceCarcinoma, Squamous CellConfidence IntervalsDatabases, FactualDisease-Free SurvivalFemaleHumansMaleMiddle AgedMouth NeoplasmsMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingOral Surgical ProceduresPrognosisRetrospective StudiesRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsOral cavity cancerEarly oral cavity cancerPositive surgical marginsPositive marginsMargin statusSurgical marginsCase volumeEarly-stage oral cavity cancerOral cavity squamous cell cancerDifficulty of resectionNational Cancer DatabaseStage II diseaseEarly oral cancerHospital case volumeSquamous cell cancerTreatment facility typeFloor of mouthQuality of careUseful quality measureTumor factorsClinical factorsCell cancerCancer CenterOral cancerCancer DatabaseSubscapular system of flaps: An 8‐year experience with 105 patients
Gibber MJ, Clain JB, Jacobson AS, Buchbinder D, Scherl S, Zevallos JP, Mehra S, Urken ML. Subscapular system of flaps: An 8‐year experience with 105 patients. Head & Neck 2014, 37: 1200-1206. PMID: 24800735, DOI: 10.1002/hed.23738.Peer-Reviewed Original ResearchConceptsSubscapular systemFree flapRetrospective medical chart reviewExtensive surgical defectsMedical chart reviewOverall success rateDonor siteSoft tissue componentSoft tissue elementsLarge muscle flapsChart reviewEarly mobilizationAlternative donor siteMuscle flapAdvanced agePatientsNeck reconstructionSurgical defectsVital structuresFirst choiceMaxillary defectsFlapMandibular defectsSuccess rateNoninvasive Anaplastic Thyroid Carcinoma: Report of a Case and Literature Review
Dibelius G, Mehra S, Clain JB, Urken ML, Wenig BM. Noninvasive Anaplastic Thyroid Carcinoma: Report of a Case and Literature Review. Thyroid 2014, 24: 1319-1324. PMID: 24865498, DOI: 10.1089/thy.2013.0586.Peer-Reviewed Original ResearchConceptsAnaplastic thyroid carcinomaPositron emission tomography/American Thyroid Association guidelinesFine-needle aspiration biopsyManagement of patientsSeparate disease entityEmission tomography/Evidence of invasionSimilar casesUncommon thyroid malignancyAdjuvant therapyTotal thyroidectomyDistant metastasisFavorable prognosisPreoperative imagingTomography/Disease freeImmunohistochemical evaluationAssociation guidelinesDisease entityThyroid malignancyThyroid carcinomaAspiration biopsyThyroid tumorsPatientsThe Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer?
Scherl S, Mehra S, Clain J, Dos Reis LL, Persky M, Turk A, Wenig B, Husaini H, Urken ML. The Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer? Thyroid 2014, 24: 1282-1288. PMID: 24787362, DOI: 10.1089/thy.2013.0600.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCarcinomaCarcinoma, PapillaryFalse Negative ReactionsFalse Positive ReactionsFemaleHashimoto DiseaseHumansIntraoperative PeriodLymph NodesLymphatic MetastasisMaleMiddle AgedNeck DissectionProfessional CompetenceRiskSensitivity and SpecificitySurgeonsThyroid Cancer, PapillaryThyroid NeoplasmsThyroidectomyYoung AdultConceptsProphylactic central neck dissectionPapillary thyroid cancerMetastatic lymph nodesExtranodal extensionLymph nodesOccult metastasesPositive nodesSurgeon experienceOccult nodesPathologic featuresThyroid cancerPresence of ENECentral compartment lymph nodesAdverse histologic featuresMultiple positive nodesPositive central nodesSenior surgeon's assessmentCentral neck dissectionFalse-negative casesGroup of surgeonsEvident nodesPreoperative evidenceProphylactic dissectionNeck dissectionRisk stratification
2013
Factors Predictive of Voice and Swallowing Outcomes after Anterior Approaches to the Cervical Spine
Mehra S, Heineman TE, Cammisa FP, Girardi FP, Sama AA, Kutler DI. Factors Predictive of Voice and Swallowing Outcomes after Anterior Approaches to the Cervical Spine. Otolaryngology 2013, 150: 259-265. PMID: 24367048, DOI: 10.1177/0194599813515414.Peer-Reviewed Original ResearchConceptsAnterior transcervical approachSpinal levelAnterior approachSurgical factorsCervical spineTranscervical approachPostoperative voiceHistorical cohort studyKaplan-Meier methodVoice complaintsCervical spine diseaseAcademic medical centerSwallowing complaintsCohort studySwallowing outcomesConsecutive patientsMedian timePostoperative issuesSwallowing problemsFactors PredictiveSpine diseaseNeck surgeonsMedical CenterHigh incidencePatients
2011
Predictors of survival and recurrence after temporal bone resection for cancer
Morris LG, Mehra S, Shah JP, Bilsky MH, Selesnick SH, Kraus DH. Predictors of survival and recurrence after temporal bone resection for cancer. Head & Neck 2011, 34: 1231-1239. PMID: 21953902, PMCID: PMC4126564, DOI: 10.1002/hed.21883.Peer-Reviewed Original ResearchConceptsTemporal bone resectionSquamous cell carcinomaDisease-specific survivalRecurrence-free survivalExternal auditory canalOverall survivalMargin statusAuditory canalBone resectionCT3-4 tumorsParotid nodal metastasisT3-T4 tumorsPredictors of survivalRisk of recurrenceStrong independent predictorHigh rateExtratemporal spreadParotid invasionAdjuvant therapyCervical metastasisIndependent predictorsNodal metastasisMultivariable analysisRetrospective studyCell carcinoma