NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
Panaccione A, Chang MT, Carbone BE, Guo Y, Moskaluk CA, Virk RK, Chiriboga L, Prasad ML, Judson B, Mehra S, Yarbrough WG, Ivanov SV. NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma. Clinical Cancer Research 2016, 22: 2083-2095. PMID: 27084744, PMCID: PMC4834904, DOI: 10.1158/1078-0432.ccr-15-2208.Peer-Reviewed Original ResearchMeSH KeywordsAC133 AntigenAmyloid Precursor Protein SecretasesAnimalsBiomarkers, TumorCarcinoma, Adenoid CysticCell Line, TumorCell Transformation, NeoplasticCyclin-Dependent Kinase Inhibitor p27Disease Models, AnimalFatty Acid-Binding Protein 7Gene Expression ProfilingHeterograftsHumansLigandsMiceMice, NudeNeoplasm GradingNeoplastic Stem CellsProtein BindingRadiationRadiation ToleranceReceptor, Notch1SOXE Transcription FactorsS-Phase Kinase-Associated ProteinsTumor Cells, CulturedTumor Suppressor ProteinsConceptsCancer stem cellsRibosome biogenesisCancer stem-like cellsStem-like cellsLack of assaysCSC maintenanceMolecular markersNeural differentiationCell deathUncharacterized populationACC therapyΓ-secretase inhibitorCSC viabilityCD133-positive cancer stem cellsStem cellsCell sortingSOX10Essential roleSkp2Notch1P27Kip1Stem propertiesCell culturesImmunomagnetic cell sortingCells