2020
Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder
Yao YW, Liu L, Worhunsky PD, Lichenstein S, Ma SS, Zhu L, Shi XH, Yang S, Zhang JT, Yip SW. Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder. NeuroImage Clinical 2020, 26: 102202. PMID: 32045732, PMCID: PMC7013339, DOI: 10.1016/j.nicl.2020.102202.Peer-Reviewed Original ResearchConceptsMonetary reward processingInternet gaming disorderReward processingBehavioral addictionsSubstance use disordersNeural responsesGaming disorderMonetary incentive delay taskCurrent fMRI studyDrug-naïve young adultsNon-drug rewardsAltered reward processingIncentive delay taskDrug-naïve youthUse disordersDelay taskProcessing alterationsCaudate activityFMRI studyDrugs of abuseTrait featuresNeural activityNeural featuresOutcome stageSubstance exposure
2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2017
Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder
Yip SW, Gross JJ, Chawla M, Ma SS, Shi XH, Liu L, Yao YW, Zhu L, Worhunsky PD, Zhang J. Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder. Neuropsychopharmacology 2017, 43: 1364-1372. PMID: 29154365, PMCID: PMC5916358, DOI: 10.1038/npp.2017.283.Peer-Reviewed Original ResearchConceptsDrug-naïve youthNeural processingEmotion regulationNegative affectGaming disorderGroup differencesEmotion regulation taskNegative affective cuesNegative affective stimuliLateral prefrontal cortexInternet gaming disorderAffective cuesAffective stimuliNegative stimuliFMRI scanningIndependent component analysisTask performanceMixed-effects ANOVASubstance use disordersNeural responsesRegulation taskAddictive behaviorsBehavioral addictionsPrefrontal cortexDrugs of abuse
2016
Intra-individual changes in Stroop-related activations linked to cigarette abstinence in adolescent tobacco smokers: Preliminary findings
Yip SW, Balodis IM, Carroll KM, Krishnan-Sarin S, Potenza MN. Intra-individual changes in Stroop-related activations linked to cigarette abstinence in adolescent tobacco smokers: Preliminary findings. Drug And Alcohol Dependence 2016, 167: 182-189. PMID: 27567966, PMCID: PMC5082713, DOI: 10.1016/j.drugalcdep.2016.08.019.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCognitive control taskStroop task performanceAdolescent tobacco smokersMore effective treatment interventionsCessation treatmentIntra-individual changesEffective treatment interventionsSuccessful behavioral changeIndividual-level changeGroup-level changesCognitive efficiencyBrain mechanismsFMRI scanningTask performanceNeural mechanismsNeural responsesNeural activityFMRI dataControl taskStroopTreatment interventionsMain effectCigarette abstinenceOptimal treatment responseAnticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug And Alcohol Dependence 2016, 166: 134-142. PMID: 27430401, PMCID: PMC5082418, DOI: 10.1016/j.drugalcdep.2016.07.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentCocaine-dependent individualsBOLD responseCocaine dependenceSignificant public health problemMethadone-maintained individualsMethadone-maintained populationsMethadone-maintained patientsElevated relapse ratesPublic health problemCocaine-negative urinesCocaine-dependent patientsAnticipatory reward processingPosterior cingulate cortexLoss processingDuration of abstinenceDorsolateral prefrontal cortexCD patientsRelapse rateWhole-brain ANOVAInferior frontal gyrusTreatment outcomesRight caudateHealthy comparison participantsPatients
2014
Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder
Yip SW, Worhunsky PD, Rogers RD, Goodwin GM. Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder. Neuropsychopharmacology 2014, 40: 658-666. PMID: 25139065, PMCID: PMC4289954, DOI: 10.1038/npp.2014.215.Peer-Reviewed Original ResearchConceptsDorsal striatumUnmedicated individualsLoss anticipationPotential ameliorative effectsAddiction-related disordersBipolar disorder IReward processingMonetary incentive delay taskSmall volume correctionFunctional magnetic resonanceIncentive delay taskAntipsychotic medicationVentral striatal activityHealthy comparison individualsPutamen volumeBipolar disorderBD-IIAmeliorative effectMedicated individualsStriatal activityDisorder IStriatumGroup comparisonsNeural activationReward anticipationPretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Pretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1. Drug And Alcohol Dependence 2014, 140: 33-41. PMID: 24793365, PMCID: PMC4057888, DOI: 10.1016/j.drugalcdep.2014.03.031.Peer-Reviewed Original ResearchConceptsCannabis-dependent participantsMagnetic resonance imagingCannabis dependenceHC participantsTreatment responseConsecutive abstinenceHealthy comparison menBilateral putamen volumesCannabis-dependent individualsSuccessful treatment outcomeEfficacy of therapeuticsDays of abstinenceVentral striatal activationClinical trialsStriatal functionTreatment outcomesMRI scanningComparison menPutamen volumeResonance imagingBehavioral treatmentBiological markersBrain functionBrain structuresAbstinence
2013
Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy
Godlewska BR, Yip SW, Near J, Goodwin GM, Cowen PJ. Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy. Psychopharmacology 2013, 231: 327-332. PMID: 23955702, DOI: 10.1007/s00213-013-3244-0.Peer-Reviewed Original ResearchConceptsBipolar disorderGSH levelsOccipital cortexHealthy age-matched controlsPilot studyDSM-IV bipolar disorderPost-mortem brain tissueConclusionsThis pilot studyAge-matched controlsProton magnetic resonance spectroscopyTime of studyMagnetic resonance spectroscopyCortical GSHIll patientsCortical metabolitesΓ-aminobutyric acidCellular free radicalsMood disturbanceUseful biomarkerBipolar pathophysiologyPatientsTrait biomarkerBrain tissueGlutathione levelsObjectivesThe objective
2012
Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype
Yip SW, Doherty J, Wakeley J, Saunders K, Tzagarakis C, de Wit H, Goodwin GM, Rogers RD. Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype. Neuropsychopharmacology 2012, 37: 1808-1815. PMID: 22491350, PMCID: PMC3376329, DOI: 10.1038/npp.2012.45.Peer-Reviewed Original ResearchConceptsAlcohol use disorderWeekly alcohol intakeBipolar disorderAlcohol intakeSubjective responsesAcute ethanol administrationLifetime prevalence ratesDevelopment of AUDPlacebo administrationAcute alcoholEthanol administrationHealthy controlsSedative responsePharmacokinetic effectsEtiological factorsPrevalence ratesUse disordersAlcohol misusePharmacokinetic responseFamilial riskAlcohol responsesYoung malesIntoxication effectsBipolar phenotypeYoung men
2011
Health/Functioning Characteristics, Gambling Behaviors, and Gambling‐Related Motivations in Adolescents Stratified by Gambling Problem Severity: Findings from a High School Survey
Yip SW, Desai RA, Steinberg MA, Rugle L, Cavallo DA, Krishnan‐Sarin S, Potenza MN. Health/Functioning Characteristics, Gambling Behaviors, and Gambling‐Related Motivations in Adolescents Stratified by Gambling Problem Severity: Findings from a High School Survey. American Journal On Addictions 2011, 20: 495-508. PMID: 21999494, PMCID: PMC3683237, DOI: 10.1111/j.1521-0391.2011.00180.x.Peer-Reviewed Original ResearchConceptsProblem severityDSM-IV criteriaPathological gamblingDysphoria/depressionMeasures of healthGambling problem severityProblem/pathological gamblingSubstance useGeneral functioningImproved interventionsSeverityPoor academic performanceProtective behaviorsHigh school surveySchool surveyAdditional researchGambling behaviorFindings
2009
Risk/reward decision-making in schizophrenia: A preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance
Yip SW, Sacco KA, George TP, Potenza MN. Risk/reward decision-making in schizophrenia: A preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance. Schizophrenia Research 2009, 110: 156-164. PMID: 19269138, PMCID: PMC2817985, DOI: 10.1016/j.schres.2009.01.012.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TaskIowa Gambling TaskTask performanceCard Sorting TaskSchizophrenia show deficitsRisk/rewardNon-psychiatric controlsNeurocognitive tasksGambling TaskCognitive functioningIGT performanceSorting TaskWCST performanceComputerized versionRisk/TaskSchizophreniaDeficitsMixed resultsSubject groupsPreliminary examinationIndividualsClinical factorsFurther researchTobacco smoking