Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder
Yip SW, Worhunsky PD, Rogers RD, Goodwin GM. Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder. Neuropsychopharmacology 2014, 40: 658-666. PMID: 25139065, PMCID: PMC4289954, DOI: 10.1038/npp.2014.215.Peer-Reviewed Original ResearchConceptsDorsal striatumUnmedicated individualsLoss anticipationPotential ameliorative effectsAddiction-related disordersBipolar disorder IReward processingMonetary incentive delay taskSmall volume correctionFunctional magnetic resonanceIncentive delay taskAntipsychotic medicationVentral striatal activityHealthy comparison individualsPutamen volumeBipolar disorderBD-IIAmeliorative effectMedicated individualsStriatal activityDisorder IStriatumGroup comparisonsNeural activationReward anticipationPretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1
Yip SW, DeVito EE, Kober H, Worhunsky PD, Carroll KM, Potenza MN. Pretreatment measures of brain structure and reward-processing brain function in cannabis dependence: An exploratory study of relationships with abstinence during behavioral treatment 1. Drug And Alcohol Dependence 2014, 140: 33-41. PMID: 24793365, PMCID: PMC4057888, DOI: 10.1016/j.drugalcdep.2014.03.031.Peer-Reviewed Original ResearchConceptsCannabis-dependent participantsMagnetic resonance imagingCannabis dependenceHC participantsTreatment responseConsecutive abstinenceHealthy comparison menBilateral putamen volumesCannabis-dependent individualsSuccessful treatment outcomeEfficacy of therapeuticsDays of abstinenceVentral striatal activationClinical trialsStriatal functionTreatment outcomesMRI scanningComparison menPutamen volumeResonance imagingBehavioral treatmentBiological markersBrain functionBrain structuresAbstinence