2020
Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder
Yao YW, Liu L, Worhunsky PD, Lichenstein S, Ma SS, Zhu L, Shi XH, Yang S, Zhang JT, Yip SW. Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder. NeuroImage Clinical 2020, 26: 102202. PMID: 32045732, PMCID: PMC7013339, DOI: 10.1016/j.nicl.2020.102202.Peer-Reviewed Original ResearchConceptsMonetary reward processingInternet gaming disorderReward processingBehavioral addictionsSubstance use disordersNeural responsesGaming disorderMonetary incentive delay taskCurrent fMRI studyDrug-naïve young adultsNon-drug rewardsAltered reward processingIncentive delay taskDrug-naïve youthUse disordersDelay taskProcessing alterationsCaudate activityFMRI studyDrugs of abuseTrait featuresNeural activityNeural featuresOutcome stageSubstance exposure
2017
Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder
Yip SW, Gross JJ, Chawla M, Ma SS, Shi XH, Liu L, Yao YW, Zhu L, Worhunsky PD, Zhang J. Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naïve Youth with Internet Gaming Disorder. Neuropsychopharmacology 2017, 43: 1364-1372. PMID: 29154365, PMCID: PMC5916358, DOI: 10.1038/npp.2017.283.Peer-Reviewed Original ResearchConceptsDrug-naïve youthNeural processingEmotion regulationNegative affectGaming disorderGroup differencesEmotion regulation taskNegative affective cuesNegative affective stimuliLateral prefrontal cortexInternet gaming disorderAffective cuesAffective stimuliNegative stimuliFMRI scanningIndependent component analysisTask performanceMixed-effects ANOVASubstance use disordersNeural responsesRegulation taskAddictive behaviorsBehavioral addictionsPrefrontal cortexDrugs of abuseAltered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents
Zakiniaeiz Y, Yip SW, Balodis IM, Lacadie CM, Scheinost D, Constable RT, Mayes LC, Sinha R, Potenza MN. Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents. Drug And Alcohol Dependence 2017, 180: 129-136. PMID: 28888152, PMCID: PMC5808433, DOI: 10.1016/j.drugalcdep.2017.07.030.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureNeutral-relaxing conditionsPCE adolescentsParietal connectivityConnectivity analysisSensory areasAdolescent brain functionFunctional magnetic resonance imagingCue interaction effectsIntrinsic connectivity analysesMedial prefrontal areasSeed-based connectivity analysisSubstance Use InitiationAltered functional connectivityAppetitive cuesObesity vulnerabilityPCE statusNeural responsesCorticolimbic connectivityPrefrontal areasFunctional connectivityCraving scoresUtero drug exposureGroup differencesLess connectivityReward-related frontostriatal activity and smoking behavior among adolescents in treatment for smoking cessation
Garrison KA, Yip SW, Balodis IM, Carroll KM, Potenza MN, Krishnan-Sarin S. Reward-related frontostriatal activity and smoking behavior among adolescents in treatment for smoking cessation. Drug And Alcohol Dependence 2017, 177: 268-276. PMID: 28651213, PMCID: PMC5564393, DOI: 10.1016/j.drugalcdep.2017.03.035.Peer-Reviewed Original ResearchConceptsAdolescent smokersReward anticipationNeural responsesMonetary incentive delay taskBehavioral Activation ScaleIncentive delay taskNeural reward systemVentral striatal activationCessation treatmentMedial prefrontal cortexBilateral nucleus accumbensNeural correlatesSmoking cessation treatmentActivation ScalesBehavioral inhibitionFrontostriatal responseDelay taskFrontostriatal activityAdolescent nonsmokersStriatal activationPrefrontal cortexEffective smoking cessation interventionsReward systemSmoking cessation interventionTobacco use disorder
2016
Intra-individual changes in Stroop-related activations linked to cigarette abstinence in adolescent tobacco smokers: Preliminary findings
Yip SW, Balodis IM, Carroll KM, Krishnan-Sarin S, Potenza MN. Intra-individual changes in Stroop-related activations linked to cigarette abstinence in adolescent tobacco smokers: Preliminary findings. Drug And Alcohol Dependence 2016, 167: 182-189. PMID: 27567966, PMCID: PMC5082713, DOI: 10.1016/j.drugalcdep.2016.08.019.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingCognitive control taskStroop task performanceAdolescent tobacco smokersMore effective treatment interventionsCessation treatmentIntra-individual changesEffective treatment interventionsSuccessful behavioral changeIndividual-level changeGroup-level changesCognitive efficiencyBrain mechanismsFMRI scanningTask performanceNeural mechanismsNeural responsesNeural activityFMRI dataControl taskStroopTreatment interventionsMain effectCigarette abstinenceOptimal treatment response
2015
Prenatal cocaine exposure, illicit-substance use and stress and craving processes during adolescence
Yip SW, Lacadie CM, Sinha R, Mayes LC, Potenza MN. Prenatal cocaine exposure, illicit-substance use and stress and craving processes during adolescence. Drug And Alcohol Dependence 2015, 158: 76-85. PMID: 26627911, PMCID: PMC4698087, DOI: 10.1016/j.drugalcdep.2015.11.012.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureIllicit substance useNeural responsesCocaine exposureFunctional neural responsesFunctional magnetic resonance imaging (fMRI) dataDifferent neural substratesOngoing longitudinal studyThree-way interactionCortical brain regionsCue conditionImagery scriptsPCE statusAdolescent developmentStress processingNeural substratesIllicit substance usersPrefrontal cortexRight insulaMagnetic resonance imaging dataNeural activityUtero cocaine exposureSubjective ratingsCortical activityOpposite pattern
2014
Prenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli
Yip SW, Potenza EB, Balodis IM, Lacadie CM, Sinha R, Mayes LC, Potenza MN. Prenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli. Neuropsychopharmacology 2014, 39: 2824-2834. PMID: 24903650, PMCID: PMC4200493, DOI: 10.1038/npp.2014.133.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureFavorite-food cuesFunctional magnetic resonance imagingPCE adolescentsPrefrontal cortexVentral striatumNeural responsesBrain regionsAdolescents' neural responsesSubjective food cravingsDorsolateral PFC activationSubjective anxiety ratingsDorsolateral prefrontal cortexCocaine exposureSubcortical brain regionsDevelopment of addictionPFC activationEmotional regulationHuman adolescentsSubstance use disordersAppetitive processingMotivational controlAddiction vulnerabilityHippocampus activityFood cravings